Methods for identifying virus-derived serpins

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The serpin family of serine proteinase inhibitors plays key roles in the maintenance of mammalian homeostasis. Virus-encoded serpins disrupt the balance of mammalian proteases to facilitate virus replication in the infected host. DNA viruses, in particular members of the poxvirus family, have acquired multiple copies of the functional serpins which are essential for viral pathogenesis. Virus-encoded serpins have proven to be very effective inhibitors of host proteases and thus are very attractive candidate molecules as immunomodulatory drugs. With this chapter we explain approaches to identifying immune-modulating viral serpins.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages73-86
Number of pages14
DOIs
StatePublished - Jan 1 2018

Publication series

NameMethods in Molecular Biology
Volume1826
ISSN (Print)1064-3745

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Keywords

  • Immunomodulatory drugs
  • Knockout virus
  • Myxoma virus
  • Poxvirus
  • SERP-1
  • Serpins

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Rahman, M. (2018). Methods for identifying virus-derived serpins. In Methods in Molecular Biology (pp. 73-86). (Methods in Molecular Biology; Vol. 1826). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8645-3_5