Abstract
Background Studying the physiologic effects of components of fine particulate mass (PM2.5) could contribute to a better understanding of the nature of toxicity of air pollution. Objectives We examined the relation between acute changes in cardiovascular and respiratory function, and PM 2.5-associated-metals. Methods Using generalized linear mixed models, daily changes in ambient PM2.5-associated metals were compared to daily changes in physiologic measures in 59 healthy subjects who spent 5-days near a steel plant and 5-days on a college campus. Results Interquartile increases in calcium, cadmium, lead, strontium, tin, vanadium and zinc were associated with statistically significant increases in heart rate of 1-3 beats per minute, increases of 1-3 mmHg in blood pressure and/or lung function decreases of up to 4% for total lung capacity. Conclusion Metals contained in PM2.5 were found to be associated with acute changes in cardiovascular and respiratory physiology.
Original language | English (US) |
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Pages (from-to) | 208-214 |
Number of pages | 7 |
Journal | Environmental Pollution |
Volume | 189 |
DOIs | |
State | Published - Jun 2014 |
Externally published | Yes |
Keywords
- Air pollution
- Epidemiology
- Fine particulate air pollution
- Metals
- Steel production
ASJC Scopus subject areas
- Toxicology
- Pollution
- Health, Toxicology and Mutagenesis