Two novel approaches have been employed for mediating RNA strand scission under physiological conditions. One of these involved strand scission by an Fe2+ chelate of the antitumor antibiotic bleomycin; the other involved a novel Mn2+-dependent cleavage of an RNA hairpin at a specific site. Bleomycin-mediated RNA cleavage was oxidative in nature, while the Mn2+-promoted cleavage of the hairpin occurred by a solvolytic mechanism.
|Original language||English (US)|
|Number of pages||13|
|Journal||Nucleosides and Nucleotides|
|State||Published - Jan 1 1991|
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