Metal-catalyzed rna strand scission

Barbara J. Carter; Chris E. Holmes; Reuel B. Van Atta; V. Dange; Sidney M. Hecht

doi:10.1080/07328319108046448

Metal-catalyzed rna strand scission

Barbara J. Carter, Chris E. Holmes, Reuel B. Van Atta, V. Dange, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Two novel approaches have been employed for mediating RNA strand scission under physiological conditions. One of these involved strand scission by an Fe²⁺ chelate of the antitumor antibiotic bleomycin; the other involved a novel Mn²⁺-dependent cleavage of an RNA hairpin at a specific site. Bleomycin-mediated RNA cleavage was oxidative in nature, while the Mn²⁺-promoted cleavage of the hairpin occurred by a solvolytic mechanism.

Original language	English (US)
Pages (from-to)	215-227
Number of pages	13
Journal	Nucleosides and Nucleotides
Volume	10
Issue number	1-3
DOIs	https://doi.org/10.1080/07328319108046448
State	Published - Jan 1 1991
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Genetics

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abstract = "Two novel approaches have been employed for mediating RNA strand scission under physiological conditions. One of these involved strand scission by an Fe2+ chelate of the antitumor antibiotic bleomycin; the other involved a novel Mn2+-dependent cleavage of an RNA hairpin at a specific site. Bleomycin-mediated RNA cleavage was oxidative in nature, while the Mn2+-promoted cleavage of the hairpin occurred by a solvolytic mechanism.",

author = "Carter, {Barbara J.} and Holmes, {Chris E.} and {Van Atta}, {Reuel B.} and V. Dange and Hecht, {Sidney M.}",

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T1 - Metal-catalyzed rna strand scission

AU - Carter, Barbara J.

AU - Holmes, Chris E.

AU - Van Atta, Reuel B.

AU - Dange, V.

AU - Hecht, Sidney M.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Two novel approaches have been employed for mediating RNA strand scission under physiological conditions. One of these involved strand scission by an Fe2+ chelate of the antitumor antibiotic bleomycin; the other involved a novel Mn2+-dependent cleavage of an RNA hairpin at a specific site. Bleomycin-mediated RNA cleavage was oxidative in nature, while the Mn2+-promoted cleavage of the hairpin occurred by a solvolytic mechanism.

AB - Two novel approaches have been employed for mediating RNA strand scission under physiological conditions. One of these involved strand scission by an Fe2+ chelate of the antitumor antibiotic bleomycin; the other involved a novel Mn2+-dependent cleavage of an RNA hairpin at a specific site. Bleomycin-mediated RNA cleavage was oxidative in nature, while the Mn2+-promoted cleavage of the hairpin occurred by a solvolytic mechanism.

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M3 - Article

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JF - Nucleosides and Nucleotides

IS - 1-3

ER -

Metal-catalyzed rna strand scission

Abstract

ASJC Scopus subject areas

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