Metal-catalyzed rna strand scission

Barbara J. Carter, Chris E. Holmes, Reuel B. Van Atta, V. Dange, Sidney M. Hecht

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Two novel approaches have been employed for mediating RNA strand scission under physiological conditions. One of these involved strand scission by an Fe2+ chelate of the antitumor antibiotic bleomycin; the other involved a novel Mn2+-dependent cleavage of an RNA hairpin at a specific site. Bleomycin-mediated RNA cleavage was oxidative in nature, while the Mn2+-promoted cleavage of the hairpin occurred by a solvolytic mechanism.

Original languageEnglish (US)
Pages (from-to)215-227
Number of pages13
JournalNucleosides and Nucleotides
Volume10
Issue number1-3
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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