@inbook{8ba09f6436c540c9948dcb3678776459,
title = "Metabotropic glutamate receptors and cognition: From underlying plasticity and neuroprotection to cognitive disorders and therapeutic targets",
abstract = "Metabotropic glutamate (mGlu) receptors are G protein-coupled receptors that play pivotal roles in mediating the activity of neurons and other cell types within the brain, communication between cell types, synaptic plasticity, and gene expression. As such, these receptors play an important role in a number of cognitive processes. In this chapter, we discuss the role of mGlu receptors in various forms of cognition and their underlying physiology, with an emphasis on cognitive dysfunction. Specifically, we highlight evidence that links mGlu physiology to cognitive dysfunction across brain disorders including Parkinson's disease, Alzheimer's disease, Fragile X syndrome, post-traumatic stress disorder, and schizophrenia. We also provide recent evidence demonstrating that mGlu receptors may elicit neuroprotective effects in particular disease states. Lastly, we discuss how mGlu receptors can be targeted utilizing positive and negative allosteric modulators as well as subtype specific agonists and antagonist to restore cognitive function across these disorders.",
keywords = "Cognition, Excitatory transmission, Glutamate, Metabotropic receptor, Plasticity",
author = "Hoglund, {Brandon K.} and Vincent Carfagno and Olive, {M. Foster} and Leyrer-Jackson, {Jonna M.}",
note = "Funding Information: This work was supported by Public Health Service grants F32AA027962 to J.M.L.J., as well as DA043172 and AA025590 to M.F.O. Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",
year = "2023",
month = jan,
doi = "10.1016/bs.irn.2022.10.004",
language = "English (US)",
isbn = "9780323993944",
series = "International Review of Neurobiology",
publisher = "Academic Press Inc",
pages = "367--413",
editor = "Knackstedt, {Lori A.} and Knackstedt, {Lori A.} and Knackstedt, {Lori A.} and Marek Schwendt and Marek Schwendt and Marek Schwendt",
booktitle = "Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders",
}