Metabolomics-based methods for early disease diagnostics

G. A.Nagana Gowda, Shucha Zhang, Haiwei Gu, Vincent Asiago, Narasimhamurthy Shanaiah, Daniel Raftery

Research output: Contribution to journalReview article

361 Scopus citations

Abstract

The emerging field of metabolomics, in which a large number of small-molecule metabolites from body fluids or tissues are detected quantitatively in a single step, promises immense potential for early diagnosis, therapy monitoring and for understanding the pathogenesis of many diseases. Metabolomics methods are mostly focused on the information-rich analytical techniques of NMR spectroscopy and mass spectrometry (MS). Analysis of the data from these high-resolution methods using advanced chemometric approaches provides a powerful platform for translational and clinical research and diagnostic applications. In this review, the current trends and recent advances in NMR- and MS-based metabolomics are described with a focus on the development of advanced NMR and MS methods, improved multivariate statistical data analysis and recent applications in the area of cancer, diabetes, inborn errors of metabolism and cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)617-633
Number of pages17
JournalExpert Review of Molecular Diagnostics
Volume8
Issue number5
DOIs
StatePublished - Sep 1 2008
Externally publishedYes

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Keywords

  • Cancer
  • Coronary heart disease
  • Diabetes
  • Early detection
  • Inborn errors of metabolism
  • Mass spectrometry
  • Metabolomics
  • Metabonomics
  • Multivariate statistical analysis
  • NMR spectroscopy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

Cite this

Gowda, G. A. N., Zhang, S., Gu, H., Asiago, V., Shanaiah, N., & Raftery, D. (2008). Metabolomics-based methods for early disease diagnostics. Expert Review of Molecular Diagnostics, 8(5), 617-633. https://doi.org/10.1586/14737159.8.5.617