Metabolic engineering for production of biorenewable fuels and chemicals

Contributions of synthetic biology

Lonnie O. Ingram, Laura R. Jarboe, Xueli Zhang, Xuan Wang, Jonathan C. Moore, K. T. Shanmugam

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Production of fuels and chemicals through microbial fermentation of plant material is a desirable alternative to petrochemical-based production. Fermentative production of biorenewable fuels and chemicals requires the engineering of biocatalysts that can quickly and efficiently convert sugars to target products at a cost that is competitive with existing petrochemical-based processes. It is also important that biocatalysts be robust to extreme fermentation conditions, biomass-derived inhibitors, and their target products. Traditional metabolic engineering has made great advances in this area, but synthetic biology has contributed and will continue to contribute to this field, particularly with next-generation biofuels. This work reviews the use of metabolic engineering and synthetic biology in biocatalyst engineering for biorenewable fuels and chemicals production, such as ethanol, butanol, acetate, lactate, succinate, alanine, and xylitol. We also examine the existing challenges in this area and discuss strategies for improving biocatalyst tolerance to chemical inhibitors.

Original languageEnglish (US)
Article number761042
JournalJournal of Biomedicine and Biotechnology
Volume2010
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Synthetic Biology
Metabolic engineering
Metabolic Engineering
Enzymes
Petrochemicals
Fermentation
Chemical Engineering
Xylitol
Butanols
Biofuels
Succinic Acid
Sugars
Alanine
Biomass
Lactic Acid
Acetates
Ethanol
Costs and Cost Analysis
Costs

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Genetics
  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Metabolic engineering for production of biorenewable fuels and chemicals : Contributions of synthetic biology. / Ingram, Lonnie O.; Jarboe, Laura R.; Zhang, Xueli; Wang, Xuan; Moore, Jonathan C.; Shanmugam, K. T.

In: Journal of Biomedicine and Biotechnology, Vol. 2010, 761042, 2010.

Research output: Contribution to journalArticle

Ingram, Lonnie O. ; Jarboe, Laura R. ; Zhang, Xueli ; Wang, Xuan ; Moore, Jonathan C. ; Shanmugam, K. T. / Metabolic engineering for production of biorenewable fuels and chemicals : Contributions of synthetic biology. In: Journal of Biomedicine and Biotechnology. 2010 ; Vol. 2010.
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