Mesoporous carbon amperometric glucose sensors using inexpensive, commercial methacrylate-based binders

Mingzhi Dai, Stephanie Maxwell, Bryan D. Vogt, Jeffrey LaBelle

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Two ordered, soft-templated mesoporous carbon powders with cubic and hexagonal framework structure and four different commercial, low cost methacrylate-based polymer binders with widely varying physical properties are investigated as screen printed electrodes for glucose sensors using glucose oxidase and ferricyanide as the mediator. Both the chemistry and concentration of the binder in the electrode formulation can significantly impact the performance. Poly(hydroxybutyl methacrylate) as the binder provides hydrophilicity to enable transport of species in the aqueous phase to the carbon surface, but yet is sufficiently hydrophobic to provide mechanical robustness to the sensor. The current from the mesoporous carbon electrodes can be more than an order of magnitude greater than for a commercial printed carbon electrode (Zensor) with improved sensitivity for model glucose solutions. Even when applying these sensors to rabbit whole blood, the performance of these glucose sensors compares favorably to a standard commercial glucose meter with the lower detection limit of the mesoporous electrode being approximately 20mgdL -1 despite the lack of a separation membrane to prevent non-specific events; these results suggest that the small pore sizes and high surface areas associated with ordered mesoporous carbons may effectively decrease some non-specific inferences for electrochemical sensing.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalAnalytica Chimica Acta
Volume738
DOIs
StatePublished - Aug 13 2012

Fingerprint

Amperometric sensors
Glucose sensors
Methacrylates
Binders
Electrodes
electrode
glucose
Carbon
sensor
Glucose
carbon
Glucose Oxidase
Sensors
Hydrophilicity
Hydrophobic and Hydrophilic Interactions
Powders
Pore size
Blood Glucose
Limit of Detection
Polymers

Keywords

  • Biosensor
  • Diabetes mellitus
  • Electrochemistry
  • Glucose monitoring
  • Mesoporous carbon

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

Cite this

Mesoporous carbon amperometric glucose sensors using inexpensive, commercial methacrylate-based binders. / Dai, Mingzhi; Maxwell, Stephanie; Vogt, Bryan D.; LaBelle, Jeffrey.

In: Analytica Chimica Acta, Vol. 738, 13.08.2012, p. 27-34.

Research output: Contribution to journalArticle

Dai, Mingzhi ; Maxwell, Stephanie ; Vogt, Bryan D. ; LaBelle, Jeffrey. / Mesoporous carbon amperometric glucose sensors using inexpensive, commercial methacrylate-based binders. In: Analytica Chimica Acta. 2012 ; Vol. 738. pp. 27-34.
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