Mercury, lead, and zinc in baby teeth of children with autism versus controls

James Adams, Jane Romdalvik, V. M Sadagopa Ramanujam, Marvin S. Legator

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

This study determined the level of mercury, lead, and zinc in baby teeth of children with autism spectrum disorder (n = 15, age 6.1 ± 2.2 yr) and typically developing children (n = 11, age = 7 ± 1.7 yr). Children with autism had significantly (2.1-fold) higher levels of mercury but similar levels of lead and similar levels of zinc. Children with autism also had significantly higher usage of oral antibiotics during their first 12 mo of life, and possibly higher usage of oral antibiotics during their first 36 mo of life. Baby teeth are a good measure of cumulative exposure to toxic metals during fetal development and early infancy, so this study suggests that children with autism had a higher body burden of mercury during fetal/infant development. Antibiotic use is known to almost completely inhibit excretion of mercury in rats due to alteration of gut flora. Thus, higher use of oral antiobiotics in the children with autism may have reduced their ability to excrete mercury, and hence may partially explain the higher level in baby teeth. Higher usage of oral antibiotics in infancy may also partially explain the high incidence of chronic gastrointestinal problems in individuals with autism.

Original languageEnglish (US)
Pages (from-to)1046-1051
Number of pages6
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
Volume70
Issue number12
DOIs
StatePublished - Jan 2007

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Deciduous Tooth
Autistic Disorder
Mercury
Zinc
Anti-Bacterial Agents
Fetal Development
Poisons
Body Burden
Aptitude
Rats
Child Development
Metals
Lead
Incidence

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Mercury, lead, and zinc in baby teeth of children with autism versus controls. / Adams, James; Romdalvik, Jane; Ramanujam, V. M Sadagopa; Legator, Marvin S.

In: Journal of Toxicology and Environmental Health - Part A: Current Issues, Vol. 70, No. 12, 01.2007, p. 1046-1051.

Research output: Contribution to journalArticle

Adams, James ; Romdalvik, Jane ; Ramanujam, V. M Sadagopa ; Legator, Marvin S. / Mercury, lead, and zinc in baby teeth of children with autism versus controls. In: Journal of Toxicology and Environmental Health - Part A: Current Issues. 2007 ; Vol. 70, No. 12. pp. 1046-1051.
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