Mercury in first-cut baby hair of children with autism versus typically-developing children

J. B. Adams, J. Romdalvik, K. E. Levine, L. W. Hu

Research output: Contribution to journalArticle

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Abstract

Children with autism were examined to determine amounts of mercury (Hg) in their baby hair and the factors that might affect Hg body burden. US children with autism (n = 78) and matched controls (n = 31) born between 1988 and 1999 were studied. Hg in first-cut baby hair was determined using cold vapor atomic fluorescence spectrometry (CVAFS). Twenty samples were split and also measured with Neutron Activation Analysis (NAA). Logistic regression analysis showed that compared to children with higher levels of mercury (above 0.55 mcg g-1), children with lower levels of mercury in their hair (below 0.55 mcg g-1) were 2.5-fold more likely to manifest with autism. Children with autism had similar mercury exposure as controls from maternal seafood and maternal dental amalgams. Children with autism also had 2.5-fold higher incidence of oral antibiotic use during their first 18 months of life. Their mothers were possibly more likely to use oral antibiotics during pregnancy or nursing. The amount of Hg in the baby hair of children with autism showed a significant correlation with the number of maternal dental amalgams. The lower level of Hg in the baby hair of children with autism indicates an altered metabolism of Hg, and may be due to a decreased ability to excrete Hg. This is consistent with usage of higher amounts of oral antibiotics, which are known to inhibit Hg excretion in rats due to alteration of gut flora, and may exert a similar effect in humans. Higher usage of oral antibiotics in infancy may also partially explain the high incidence of chronic gastrointestinal problems seen in individuals with autism.

Original languageEnglish (US)
Pages (from-to)739-753
Number of pages15
JournalToxicological and Environmental Chemistry
Volume90
Issue number4
DOIs
StatePublished - Jul 2008

Fingerprint

Autistic Disorder
Mercury
Hair
Antibiotics
hair
Anti-Bacterial Agents
Dental amalgams
antibiotics
Blood Flow Velocity
Dental Amalgam
Incidence
Neutron activation analysis
Nursing
Metabolism
Regression analysis
Spectrometry
Logistics
Rats
Fluorescence
Vapors

Keywords

  • Amalgams
  • Antibiotics
  • Autism
  • Baby hair
  • Mercury

ASJC Scopus subject areas

  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis
  • Pollution

Cite this

Mercury in first-cut baby hair of children with autism versus typically-developing children. / Adams, J. B.; Romdalvik, J.; Levine, K. E.; Hu, L. W.

In: Toxicological and Environmental Chemistry, Vol. 90, No. 4, 07.2008, p. 739-753.

Research output: Contribution to journalArticle

Adams, J. B.; Romdalvik, J.; Levine, K. E.; Hu, L. W. / Mercury in first-cut baby hair of children with autism versus typically-developing children.

In: Toxicological and Environmental Chemistry, Vol. 90, No. 4, 07.2008, p. 739-753.

Research output: Contribution to journalArticle

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