Menetrier's disease. A trivalent gastropathy

T. M. Sundt, Carolyn Compton, R. A. Malt

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Current conceptions of Menetrier's disease only obliquely resemble those originally described. Bona-fide cases are so uncommon that, of 125 cases diagnosed as Menetrier's disease, hypertrophic gastritis, or protein-losing gastropathy treated at the Massachusetts General Hospital during the 26-year period of 1962-1987, only six cases merited an unequivocal anatomic diagnosis. Two other cases previously described proved on review to be nondiagnostic in one instance and Campylobacter pylori gastritis in the other. Because abnormalities in the secretion of gastric acid and in the loss of protein from the stomach may coexist, a representation of each case in semiquantitative terms can be described on triaxial coordinates. Three patients had a hypercoagulable state, one in association with gastric carcinoma. One other case of gastric carcinoma and one of the esophageal carcinoma coexistant with Menetrier's disease were identified. Administration of subcutaneous heparin during the perioperative period to patients with Menetrier's disease is appropriate regardless of whether or not hypercoagulation or carcinoma is manifest. If treatment with anticholinergic drugs and inhibitors of gastic acid secretion fails, total gastrectomy is the best solution, because it stops protein loss, eliminates hyperchlorhydria, prevents development of gastric carcinoma, and permits anastomotic reconstruction between normal esophagus and normal small bowel.

Original languageEnglish (US)
Pages (from-to)694-701
Number of pages8
JournalAnnals of Surgery
Volume208
Issue number6
StatePublished - 1988
Externally publishedYes

Fingerprint

Hypertrophic Gastritis
Carcinoma
Stomach
Perioperative Period
Proteins
Gastric Acid
Cholinergic Antagonists
Gastritis
Gastrectomy
Helicobacter pylori
General Hospitals
Esophagus
Heparin
Acids
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Surgery

Cite this

Sundt, T. M., Compton, C., & Malt, R. A. (1988). Menetrier's disease. A trivalent gastropathy. Annals of Surgery, 208(6), 694-701.

Menetrier's disease. A trivalent gastropathy. / Sundt, T. M.; Compton, Carolyn; Malt, R. A.

In: Annals of Surgery, Vol. 208, No. 6, 1988, p. 694-701.

Research output: Contribution to journalArticle

Sundt, TM, Compton, C & Malt, RA 1988, 'Menetrier's disease. A trivalent gastropathy', Annals of Surgery, vol. 208, no. 6, pp. 694-701.
Sundt, T. M. ; Compton, Carolyn ; Malt, R. A. / Menetrier's disease. A trivalent gastropathy. In: Annals of Surgery. 1988 ; Vol. 208, No. 6. pp. 694-701.
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