Men classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit differences in lipoprotein metabolism

Kristin L. Herron, Sonia Vega-Lopez, Karin Conde, Tripurasundari Ramjiganesh, Neil S. Shachter, Maria Luz Fernandez

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the differences that occur within the plasma compartment of normolipidemic men, classified on the basis of their response to prolonged consumption of additional dietary cholesterol. Using a crossover design, 40 men aged 18-57 y were randomly allocated to an egg (640 mg/d additional dietary cholesterol) or placebo group (0 mg/d additional dietary cholesterol), for two 30-d periods, which were separated by a 3-wk washout period. Subjects were classified as hypo-[increase in plasma total cholesterol (TC) of <0.05 mmol/L for each additional 100 mg of dietary cholesterol consumed] or hyperresponders (increase in TC of ≥0.06 mmol/L for each additional 100 mg of dietary cholesterol consumed) on the basis of their plasma reaction to the additional dietary cholesterol provided. Male hyporesponders did not experience an increase in LDL cholesterol (LDL-C) or HDL cholesterol (HDL-C) during the egg period, whereas both lipoproteins were significantly (P < 0.0001 and P < 0.05, respectively) elevated in hyperresponders. Although the LDL/HDL ratio was increased in male hyperresponders after the high cholesterol period, the mean increase experienced by this population was still within National Cholesterol Education Program guidelines. Furthermore, male hyperresponders had higher lecithin cholesterol acyltransferase (P < 0.05) and cholesteryl ester transfer protein (P < 0.05) activities during the egg period, which suggests an increase in reverse cholesterol transport. These data suggest that additional dietary cholesterol does not increase the risk of developing an atherogenic lipoprotein profile in healthy men, regardless of their response classification.

Original languageEnglish (US)
Pages (from-to)1036-1042
Number of pages7
JournalJournal of Nutrition
Volume133
Issue number4
StatePublished - Apr 1 2003
Externally publishedYes

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Dietary Cholesterol
lipoproteins
Lipoproteins
cholesterol
metabolism
Cholesterol
Ovum
Cholesterol Ester Transfer Proteins
Phosphatidylcholine-Sterol O-Acyltransferase
cholesteryl ester transfer protein
LDL Cholesterol
Cross-Over Studies
HDL Cholesterol
phosphatidylcholine-choline acyltransferase
Placebos
Guidelines
Education
low density lipoprotein cholesterol
high density lipoprotein cholesterol
placebos

Keywords

  • Cholesteryl ester transfer protein
  • Dietary cholesterol
  • Lecithin:cholesterol acyltransferase
  • Men
  • Metabolic response

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Herron, K. L., Vega-Lopez, S., Conde, K., Ramjiganesh, T., Shachter, N. S., & Fernandez, M. L. (2003). Men classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit differences in lipoprotein metabolism. Journal of Nutrition, 133(4), 1036-1042.

Men classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit differences in lipoprotein metabolism. / Herron, Kristin L.; Vega-Lopez, Sonia; Conde, Karin; Ramjiganesh, Tripurasundari; Shachter, Neil S.; Fernandez, Maria Luz.

In: Journal of Nutrition, Vol. 133, No. 4, 01.04.2003, p. 1036-1042.

Research output: Contribution to journalArticle

Herron, KL, Vega-Lopez, S, Conde, K, Ramjiganesh, T, Shachter, NS & Fernandez, ML 2003, 'Men classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit differences in lipoprotein metabolism', Journal of Nutrition, vol. 133, no. 4, pp. 1036-1042.
Herron, Kristin L. ; Vega-Lopez, Sonia ; Conde, Karin ; Ramjiganesh, Tripurasundari ; Shachter, Neil S. ; Fernandez, Maria Luz. / Men classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit differences in lipoprotein metabolism. In: Journal of Nutrition. 2003 ; Vol. 133, No. 4. pp. 1036-1042.
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