Membrane Receptors for Corticosterone

A Mechanism for Rapid Behavioral Responses in an Amphibian

Frank L. Moore, Miles Orchinik

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

This paper reviews evidence that, in some cases, steroid hormones rapidly modulate behaviors by binding to specific cell-surface receptors on neurons. The evidence comes from research with an amphibian model, Taricha granulosa. In Taricha, stress and corticosterone inhibit reproductive behaviors with a rapidity that is inconsistent with traditional models for steroid action (models in which intracellular steroid receptors function as transcription factors). A series of radioligand binding assay studies identified a corticosteroid receptor in neuronal membranes that appears to mediate the rapid behavioral responses in Taricha. Studies with various steroids showed a strong correlation between their potencies to inhibit the behavior and their potencies to inhibit corticosterone binding. Neurophysiological studies of caudal brainstem neurons found that corticosterone administration rapidly modulates neuronal activity and selectively suppresses sensory processing. Another series of studies provided evidence that this corticosterone receptor interacts with G proteins in neuronal membranes. The studies suggest that there are G protein-coupled receptors for corticosteroids that provide all alternative mechanism by which this hormone regulates brain functions and behaviors.

Original languageEnglish (US)
Pages (from-to)512-519
Number of pages8
JournalHormones and Behavior
Volume28
Issue number4
DOIs
StatePublished - Dec 1994
Externally publishedYes

Fingerprint

Salamandridae
Amphibians
Corticosterone
Steroid Receptors
Steroids
Membranes
Hormones
Neurons
Reproductive Behavior
Radioligand Assay
Cell Surface Receptors
G-Protein-Coupled Receptors
GTP-Binding Proteins
Brain Stem
Adrenal Cortex Hormones
Transcription Factors
Brain
Research
corticosterone receptor

ASJC Scopus subject areas

  • Psychology(all)
  • Neurology
  • Behavioral Neuroscience
  • Endocrinology

Cite this

Membrane Receptors for Corticosterone : A Mechanism for Rapid Behavioral Responses in an Amphibian. / Moore, Frank L.; Orchinik, Miles.

In: Hormones and Behavior, Vol. 28, No. 4, 12.1994, p. 512-519.

Research output: Contribution to journalArticle

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