Meloxicam inhibits the growth of colorectal cancer cells

Angela P. Goldman, Christopher S. Williams, Hongmiao Sheng, Laura W. Lamps, Vanessa P. Williams, Michel Pairet, Jason D.morrow, Raymond N. DuBois

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    137 Scopus citations

    Abstract

    Cyclooxygenase-2 has been reported to play an important role in colorectal carcinogenesis. The effects of meloxicam (a COX-2 inhibitor) on the growth of two colon cancer cell lines that express COX-2 (HCA-7 and Moser-S) and a COX-2 negative cell line (HCT-116) were evaluated. The growth rate of these cells was measured following treatment with meloxicam. HCA-7 and Moser-S colony size were significantly reduced following treatment with meloxicam; however, there was no significant change in HCT-116 colony size with treatment. In vitro studies were performed to evaluate the effect of meloxicam on the growth of HCA-7 cells when xenografted into nude mice. We observed a 51% reduction in tumor size after 4 weeks of treatment. Analysis of COX-1 and COX-2 protein levels in HCA-7 tumor lysates revealed a slight decrease in COX-2 expression levels in tumors taken from mice treated with meloxicam and no detectable COX-1 expression. Here we report that meloxicam significantly inhibited HCA-7 colony and tumor growth but had no effect on the growth of the COX-2 negative HCT-116 cells.

    Original languageEnglish (US)
    Pages (from-to)2195-2199
    Number of pages5
    JournalCarcinogenesis
    Volume19
    Issue number12
    DOIs
    StatePublished - 1998

    ASJC Scopus subject areas

    • Cancer Research

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  • Cite this

    Goldman, A. P., Williams, C. S., Sheng, H., Lamps, L. W., Williams, V. P., Pairet, M., D.morrow, J., & DuBois, R. N. (1998). Meloxicam inhibits the growth of colorectal cancer cells. Carcinogenesis, 19(12), 2195-2199. https://doi.org/10.1093/carcin/19.12.2195