Meloxicam inhibits the growth of colorectal cancer cells

Angela P. Goldman, Christopher S. Williams, Hongmiao Sheng, Laura W. Lamps, Vanessa P. Williams, Michel Pairet, Jason D.morrow, Raymond N. DuBois

Research output: Contribution to journalArticle

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Abstract

Cyclooxygenase-2 has been reported to play an important role in colorectal carcinogenesis. The effects of meloxicam (a COX-2 inhibitor) on the growth of two colon cancer cell lines that express COX-2 (HCA-7 and Moser-S) and a COX-2 negative cell line (HCT-116) were evaluated. The growth rate of these cells was measured following treatment with meloxicam. HCA-7 and Moser-S colony size were significantly reduced following treatment with meloxicam; however, there was no significant change in HCT-116 colony size with treatment. In vitro studies were performed to evaluate the effect of meloxicam on the growth of HCA-7 cells when xenografted into nude mice. We observed a 51% reduction in tumor size after 4 weeks of treatment. Analysis of COX-1 and COX-2 protein levels in HCA-7 tumor lysates revealed a slight decrease in COX-2 expression levels in tumors taken from mice treated with meloxicam and no detectable COX-1 expression. Here we report that meloxicam significantly inhibited HCA-7 colony and tumor growth but had no effect on the growth of the COX-2 negative HCT-116 cells.

Original languageEnglish (US)
Pages (from-to)2195-2199
Number of pages5
JournalCarcinogenesis
Volume19
Issue number12
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

meloxicam
Colorectal Neoplasms
Growth
Neoplasms
HCT116 Cells
Cell Line
Cyclooxygenase 2 Inhibitors
Cyclooxygenase 2
Nude Mice
Colonic Neoplasms
Carcinogenesis

ASJC Scopus subject areas

  • Cancer Research

Cite this

Goldman, A. P., Williams, C. S., Sheng, H., Lamps, L. W., Williams, V. P., Pairet, M., ... DuBois, R. N. (1998). Meloxicam inhibits the growth of colorectal cancer cells. Carcinogenesis, 19(12), 2195-2199. https://doi.org/10.1093/carcin/19.12.2195

Meloxicam inhibits the growth of colorectal cancer cells. / Goldman, Angela P.; Williams, Christopher S.; Sheng, Hongmiao; Lamps, Laura W.; Williams, Vanessa P.; Pairet, Michel; D.morrow, Jason; DuBois, Raymond N.

In: Carcinogenesis, Vol. 19, No. 12, 1998, p. 2195-2199.

Research output: Contribution to journalArticle

Goldman, AP, Williams, CS, Sheng, H, Lamps, LW, Williams, VP, Pairet, M, D.morrow, J & DuBois, RN 1998, 'Meloxicam inhibits the growth of colorectal cancer cells', Carcinogenesis, vol. 19, no. 12, pp. 2195-2199. https://doi.org/10.1093/carcin/19.12.2195
Goldman AP, Williams CS, Sheng H, Lamps LW, Williams VP, Pairet M et al. Meloxicam inhibits the growth of colorectal cancer cells. Carcinogenesis. 1998;19(12):2195-2199. https://doi.org/10.1093/carcin/19.12.2195
Goldman, Angela P. ; Williams, Christopher S. ; Sheng, Hongmiao ; Lamps, Laura W. ; Williams, Vanessa P. ; Pairet, Michel ; D.morrow, Jason ; DuBois, Raymond N. / Meloxicam inhibits the growth of colorectal cancer cells. In: Carcinogenesis. 1998 ; Vol. 19, No. 12. pp. 2195-2199.
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