MEGA-MD: Molecular evolutionary genetics analysis software with mutational diagnosis of amino acid variation

Glen Stecher, Li Liu, Maxwell Sanderford, Daniel Peterson, Koichiro Tamura, Sudhir Kumar

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Summary: Computational diagnosis of amino acid variants in the human exome is the first step in assessing the disruptive impacts of non-synonymous single nucleotide variants (nsSNVs) on human health and disease. The Molecular Evolutionary Genetics Analysis software with mutational diagnosis (MEGA-MD) is a suite of tools developed to forecast the deleteriousness of nsSNVs using multiple methods and to explore nsSNVs in the context of the variability permitted in the longterm evolution of the affected position. In its graphical interface for use on desktops, it enables interactive computational diagnosis and evolutionary exploration of nsSNVs. As a web service, MEGA-MD is suitable for diagnosing variants on an exome scale. The MEGA-MD suite intends to serve the needs for conducting low- and high-throughput analysis of nsSNVs in diverse applications.

Original languageEnglish (US)
Pages (from-to)1305-1307
Number of pages3
JournalBioinformatics
Volume30
Issue number9
DOIs
StatePublished - May 1 2014

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Nucleotides
Amino Acids
Amino acids
Molecular Biology
Software
Exome
Throughput
High Throughput
Web Services
Forecast
Health
Web services
Genetics
Human

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Computational Mathematics
  • Statistics and Probability
  • Medicine(all)

Cite this

MEGA-MD : Molecular evolutionary genetics analysis software with mutational diagnosis of amino acid variation. / Stecher, Glen; Liu, Li; Sanderford, Maxwell; Peterson, Daniel; Tamura, Koichiro; Kumar, Sudhir.

In: Bioinformatics, Vol. 30, No. 9, 01.05.2014, p. 1305-1307.

Research output: Contribution to journalArticle

Stecher, Glen ; Liu, Li ; Sanderford, Maxwell ; Peterson, Daniel ; Tamura, Koichiro ; Kumar, Sudhir. / MEGA-MD : Molecular evolutionary genetics analysis software with mutational diagnosis of amino acid variation. In: Bioinformatics. 2014 ; Vol. 30, No. 9. pp. 1305-1307.
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