Medial demons registration localizes the degree of genetic influence over subcortical shape variability: An N= 1480 meta-analysis

Boris A. Gutman, Neda Jahanshad, Christopher R K Ching, Yalin Wang, Peter V. Kochunov, Thomas E. Nichols, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

15 Scopus citations

Abstract

We present a multi-cohort shape heritability study, extending the fast spherical demons registration to subcortical shapes via medial modeling. A multi-channel demons registration based on vector spherical harmonics is applied to medial and curvature features, while controlling for metric distortion. We registered and compared seven subcortical structures of 1480 twins and siblings from the Queensland Twin Imaging Study and Human Connectome Project: Thalamus, Caudate, Putamen, Pallidum, Hippocampus, Amygdala, and Nucleus Accumbens. Radial distance and tensor-based morphometry (TBM) features were found to be highly heritable throughout the entire basal ganglia and limbic system. Surface maps reveal subtle variation in heritability across functionally distinct parts of each structure. Medial Demons reveals more significantly heritable regions than two previously described surface registration methods. This approach may help to prioritize features and measures for genome-wide association studies.

Original languageEnglish (US)
Title of host publicationProceedings - International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
Pages1402-1406
Number of pages5
Volume2015-July
ISBN (Print)9781479923748
DOIs
StatePublished - Jul 21 2015
Event12th IEEE International Symposium on Biomedical Imaging, ISBI 2015 - Brooklyn, United States
Duration: Apr 16 2015Apr 19 2015

Other

Other12th IEEE International Symposium on Biomedical Imaging, ISBI 2015
CountryUnited States
CityBrooklyn
Period4/16/154/19/15

Keywords

  • heritability
  • medial curves
  • meta-analysis
  • shape registration
  • spherical demons

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Medial demons registration localizes the degree of genetic influence over subcortical shape variability: An N= 1480 meta-analysis'. Together they form a unique fingerprint.

  • Cite this

    Gutman, B. A., Jahanshad, N., Ching, C. R. K., Wang, Y., Kochunov, P. V., Nichols, T. E., & Thompson, P. M. (2015). Medial demons registration localizes the degree of genetic influence over subcortical shape variability: An N= 1480 meta-analysis. In Proceedings - International Symposium on Biomedical Imaging (Vol. 2015-July, pp. 1402-1406). [7164138] IEEE Computer Society. https://doi.org/10.1109/ISBI.2015.7164138