Mechanistic studies into the Raman enhancement of enediolsemiconducting nanoparticle conjugates and their use in biological applications

Sarah J. Hurst, H. Christopher Fry, David J. Gosztola, Daniel Finkelstein-Shapiro, Vladimiro Mujica, Tijana Rajh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Raman scattering enhancement was observed in systems where different metal oxide semiconductors (TiO2, Fe2O3, ZrO 2 and CeO2) were modified with enediol ligands. The intensity of Raman scattering was dependent on laser frequency and correlated with the extinction coefficient of the charge-transfer complex of the enediol ligands and nanoparticles. The intensity and frequency of the Raman bands was found to depend on the chemical composition of the enediol ligand and the chemical composition (and crystallinity) of the nanoparticles. The intensity of the Raman signal depends on the number of surface binding sites, electron density of the ligands and their dipole moment. We also found that Raman scattering is observed for the bioconjugated system, where a peptide is linked to the surface of the particle through a catechol linker. These studies are important since these bioconjugates can be used to form the basis of Raman-based, in vitro and importantly in vivo biodetection, cell labeling and imaging, and nanotherapeutic strategies.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Volume7758
DOIs
StatePublished - 2010
EventPhysical Chemistry of Interfaces and Nanomaterials IX - San Diego, CA, United States
Duration: Aug 4 2010Aug 5 2010

Other

OtherPhysical Chemistry of Interfaces and Nanomaterials IX
CountryUnited States
CitySan Diego, CA
Period8/4/108/5/10

Fingerprint

Raman Spectra
Raman
Nanoparticles
Enhancement
Ligands
Raman scattering
nanoparticles
ligands
augmentation
Raman spectra
chemical composition
Charge Transfer
TiO2
Peptides
Extinction
Dipole
Labeling
Oxides
Semiconductors
Dipole moment

Keywords

  • Biodiagnostics
  • Biomedical
  • Enediol
  • Nanoparticle
  • Nanotherapeutic
  • Peptide
  • Raman
  • TiO

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Hurst, S. J., Fry, H. C., Gosztola, D. J., Finkelstein-Shapiro, D., Mujica, V., & Rajh, T. (2010). Mechanistic studies into the Raman enhancement of enediolsemiconducting nanoparticle conjugates and their use in biological applications. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 7758). [77580E] https://doi.org/10.1117/12.862931

Mechanistic studies into the Raman enhancement of enediolsemiconducting nanoparticle conjugates and their use in biological applications. / Hurst, Sarah J.; Fry, H. Christopher; Gosztola, David J.; Finkelstein-Shapiro, Daniel; Mujica, Vladimiro; Rajh, Tijana.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7758 2010. 77580E.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hurst, SJ, Fry, HC, Gosztola, DJ, Finkelstein-Shapiro, D, Mujica, V & Rajh, T 2010, Mechanistic studies into the Raman enhancement of enediolsemiconducting nanoparticle conjugates and their use in biological applications. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 7758, 77580E, Physical Chemistry of Interfaces and Nanomaterials IX, San Diego, CA, United States, 8/4/10. https://doi.org/10.1117/12.862931
Hurst SJ, Fry HC, Gosztola DJ, Finkelstein-Shapiro D, Mujica V, Rajh T. Mechanistic studies into the Raman enhancement of enediolsemiconducting nanoparticle conjugates and their use in biological applications. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7758. 2010. 77580E https://doi.org/10.1117/12.862931
Hurst, Sarah J. ; Fry, H. Christopher ; Gosztola, David J. ; Finkelstein-Shapiro, Daniel ; Mujica, Vladimiro ; Rajh, Tijana. / Mechanistic studies into the Raman enhancement of enediolsemiconducting nanoparticle conjugates and their use in biological applications. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7758 2010.
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