Mechanism of hyperglycemia and response to treatment with an inhibitor of fatty acid oxidation in a patient with insulin resistance due to antiinsulin receptor antibodies

L. Mandarino, E. Tsalikian, S. Bartold, H. Marsh, A. Carney, E. Buerklin, G. Tutwiler, M. Haymond, B. Handwerger, R. Rizza

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Severe hyperglycemia and insulin resistance due to antiinsulin receptor antibodies developed over a period of 3 months in a 50-yr-old insulin-requiring diabetic patient. The hyperglycemia resulted from overproduction of glucose due to excessive rates of glycogenolysis and gluconeogenesis rather than decreased glucose utilization. Treatment with methyl-2-tetradecylglycidate, an inhibitor of fatty acid oxidation, resulted in a decrease in plasma glucose concentration. This was associated with a decrease in the rate of glucose production due to decreases in both gluconeogenesis and glycogenolysis rates, as well as an increase in the respiratory quotient. Plasma glucose concentrations continued to respond the drug for the next 2 months until the sudden development of terminal hypoglycemia. The hypoglycemic action of the drug is consistent with the existence of an insulin-independent effect of fatty acid oxidation on glucose metabolism in man.

Original languageEnglish (US)
Pages (from-to)658-664
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume59
Issue number4
StatePublished - 1984
Externally publishedYes

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Corrosion inhibitors
Hyperglycemia
Insulin Resistance
Fatty Acids
Insulin
Glucose
Oxidation
Antibodies
Glycogenolysis
Gluconeogenesis
Therapeutics
Plasmas
Hypoglycemia
Hypoglycemic Agents
Metabolism
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Mechanism of hyperglycemia and response to treatment with an inhibitor of fatty acid oxidation in a patient with insulin resistance due to antiinsulin receptor antibodies. / Mandarino, L.; Tsalikian, E.; Bartold, S.; Marsh, H.; Carney, A.; Buerklin, E.; Tutwiler, G.; Haymond, M.; Handwerger, B.; Rizza, R.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 59, No. 4, 1984, p. 658-664.

Research output: Contribution to journalArticle

Mandarino, L, Tsalikian, E, Bartold, S, Marsh, H, Carney, A, Buerklin, E, Tutwiler, G, Haymond, M, Handwerger, B & Rizza, R 1984, 'Mechanism of hyperglycemia and response to treatment with an inhibitor of fatty acid oxidation in a patient with insulin resistance due to antiinsulin receptor antibodies', Journal of Clinical Endocrinology and Metabolism, vol. 59, no. 4, pp. 658-664.
Mandarino, L. ; Tsalikian, E. ; Bartold, S. ; Marsh, H. ; Carney, A. ; Buerklin, E. ; Tutwiler, G. ; Haymond, M. ; Handwerger, B. ; Rizza, R. / Mechanism of hyperglycemia and response to treatment with an inhibitor of fatty acid oxidation in a patient with insulin resistance due to antiinsulin receptor antibodies. In: Journal of Clinical Endocrinology and Metabolism. 1984 ; Vol. 59, No. 4. pp. 658-664.
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AU - Tsalikian, E.

AU - Bartold, S.

AU - Marsh, H.

AU - Carney, A.

AU - Buerklin, E.

AU - Tutwiler, G.

AU - Haymond, M.

AU - Handwerger, B.

AU - Rizza, R.

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AB - Severe hyperglycemia and insulin resistance due to antiinsulin receptor antibodies developed over a period of 3 months in a 50-yr-old insulin-requiring diabetic patient. The hyperglycemia resulted from overproduction of glucose due to excessive rates of glycogenolysis and gluconeogenesis rather than decreased glucose utilization. Treatment with methyl-2-tetradecylglycidate, an inhibitor of fatty acid oxidation, resulted in a decrease in plasma glucose concentration. This was associated with a decrease in the rate of glucose production due to decreases in both gluconeogenesis and glycogenolysis rates, as well as an increase in the respiratory quotient. Plasma glucose concentrations continued to respond the drug for the next 2 months until the sudden development of terminal hypoglycemia. The hypoglycemic action of the drug is consistent with the existence of an insulin-independent effect of fatty acid oxidation on glucose metabolism in man.

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