Measurement of ocular surface protection under natural blink conditions

Richard Abelson, Keith J. Lane, Endri Angjeli, Patrick Johnston, George Ousler, Douglas Montgomery

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: To evaluate a new method of measuring ocular exposure in the context of a natural blink pattern through analysis of the variables tear film breakup time (TFBUT), interblink interval (IBI), and tear film breakup area (BUA). Methods: The traditional methodology (Forced-Stare [FS]) measures TFBUT and IBI separately. TFBUT is measured under forced-stare conditions by an examiner using a stopwatch, while IBI is measured as the subject watches television. The new methodology (video capture manual analysis [VCMA]) involves retrospective analysis of video data of fluorescein-stained eyes taken through a slit lamp while the subject watches television, and provides TFBUT and BUA for each IBI during the 1-minute video under natural blink conditions. The FS and VCMA methods were directly compared in the same set of dry-eye subjects. The VCMA method was evaluated for the ability to discriminate between dry-eye subjects and normal subjects. The VCMA method was further evaluated in the dry eye subjects for the ability to detect a treatment effect before, and 10 minutes after, bilateral instillation of an artificial tear solution. Results: Ten normal subjects and 17 dry-eye subjects were studied. In the dry-eye subjects, the two methods differed with respect to mean TFBUTs (5.82 seconds, FS; 3.98 seconds, VCMA; P = 0.002). The FS variables alone (TFBUT, IBI) were not able to successfully distinguish between the dry-eye and normal subjects, whereas the additional VCMA variables, both derived and observed (BUA, BUA/IBI, breakup rate), were able to successfully distinguish between the dry-eye and normal subjects in a statistically significant fashion. TFBUT (P = 0.034) and BUA/IBI (P = 0.001) were able to distinguish the treatment effect of artificial tears in dry-eye subjects. Conclusion: The VCMA methodology provides a clinically relevant analysis of tear film stability measured in the context of a natural blink pattern.

Original languageEnglish (US)
Pages (from-to)1349-1357
Number of pages9
JournalClinical Ophthalmology
Volume5
Issue number1
StatePublished - Sep 22 2011

Fingerprint

Tears
Television
Fluorescein

Keywords

  • Forced stare
  • Interblink interval
  • Ocular protection index
  • Tear film breakup time

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Abelson, R., Lane, K. J., Angjeli, E., Johnston, P., Ousler, G., & Montgomery, D. (2011). Measurement of ocular surface protection under natural blink conditions. Clinical Ophthalmology, 5(1), 1349-1357.

Measurement of ocular surface protection under natural blink conditions. / Abelson, Richard; Lane, Keith J.; Angjeli, Endri; Johnston, Patrick; Ousler, George; Montgomery, Douglas.

In: Clinical Ophthalmology, Vol. 5, No. 1, 22.09.2011, p. 1349-1357.

Research output: Contribution to journalArticle

Abelson, R, Lane, KJ, Angjeli, E, Johnston, P, Ousler, G & Montgomery, D 2011, 'Measurement of ocular surface protection under natural blink conditions', Clinical Ophthalmology, vol. 5, no. 1, pp. 1349-1357.
Abelson R, Lane KJ, Angjeli E, Johnston P, Ousler G, Montgomery D. Measurement of ocular surface protection under natural blink conditions. Clinical Ophthalmology. 2011 Sep 22;5(1):1349-1357.
Abelson, Richard ; Lane, Keith J. ; Angjeli, Endri ; Johnston, Patrick ; Ousler, George ; Montgomery, Douglas. / Measurement of ocular surface protection under natural blink conditions. In: Clinical Ophthalmology. 2011 ; Vol. 5, No. 1. pp. 1349-1357.
@article{e3a86c4218754d60864e6d1f22ef0c9d,
title = "Measurement of ocular surface protection under natural blink conditions",
abstract = "Purpose: To evaluate a new method of measuring ocular exposure in the context of a natural blink pattern through analysis of the variables tear film breakup time (TFBUT), interblink interval (IBI), and tear film breakup area (BUA). Methods: The traditional methodology (Forced-Stare [FS]) measures TFBUT and IBI separately. TFBUT is measured under forced-stare conditions by an examiner using a stopwatch, while IBI is measured as the subject watches television. The new methodology (video capture manual analysis [VCMA]) involves retrospective analysis of video data of fluorescein-stained eyes taken through a slit lamp while the subject watches television, and provides TFBUT and BUA for each IBI during the 1-minute video under natural blink conditions. The FS and VCMA methods were directly compared in the same set of dry-eye subjects. The VCMA method was evaluated for the ability to discriminate between dry-eye subjects and normal subjects. The VCMA method was further evaluated in the dry eye subjects for the ability to detect a treatment effect before, and 10 minutes after, bilateral instillation of an artificial tear solution. Results: Ten normal subjects and 17 dry-eye subjects were studied. In the dry-eye subjects, the two methods differed with respect to mean TFBUTs (5.82 seconds, FS; 3.98 seconds, VCMA; P = 0.002). The FS variables alone (TFBUT, IBI) were not able to successfully distinguish between the dry-eye and normal subjects, whereas the additional VCMA variables, both derived and observed (BUA, BUA/IBI, breakup rate), were able to successfully distinguish between the dry-eye and normal subjects in a statistically significant fashion. TFBUT (P = 0.034) and BUA/IBI (P = 0.001) were able to distinguish the treatment effect of artificial tears in dry-eye subjects. Conclusion: The VCMA methodology provides a clinically relevant analysis of tear film stability measured in the context of a natural blink pattern.",
keywords = "Forced stare, Interblink interval, Ocular protection index, Tear film breakup time",
author = "Richard Abelson and Lane, {Keith J.} and Endri Angjeli and Patrick Johnston and George Ousler and Douglas Montgomery",
year = "2011",
month = "9",
day = "22",
language = "English (US)",
volume = "5",
pages = "1349--1357",
journal = "Clinical Ophthalmology",
issn = "1177-5467",
publisher = "Dove Medical Press Ltd.",
number = "1",

}

TY - JOUR

T1 - Measurement of ocular surface protection under natural blink conditions

AU - Abelson, Richard

AU - Lane, Keith J.

AU - Angjeli, Endri

AU - Johnston, Patrick

AU - Ousler, George

AU - Montgomery, Douglas

PY - 2011/9/22

Y1 - 2011/9/22

N2 - Purpose: To evaluate a new method of measuring ocular exposure in the context of a natural blink pattern through analysis of the variables tear film breakup time (TFBUT), interblink interval (IBI), and tear film breakup area (BUA). Methods: The traditional methodology (Forced-Stare [FS]) measures TFBUT and IBI separately. TFBUT is measured under forced-stare conditions by an examiner using a stopwatch, while IBI is measured as the subject watches television. The new methodology (video capture manual analysis [VCMA]) involves retrospective analysis of video data of fluorescein-stained eyes taken through a slit lamp while the subject watches television, and provides TFBUT and BUA for each IBI during the 1-minute video under natural blink conditions. The FS and VCMA methods were directly compared in the same set of dry-eye subjects. The VCMA method was evaluated for the ability to discriminate between dry-eye subjects and normal subjects. The VCMA method was further evaluated in the dry eye subjects for the ability to detect a treatment effect before, and 10 minutes after, bilateral instillation of an artificial tear solution. Results: Ten normal subjects and 17 dry-eye subjects were studied. In the dry-eye subjects, the two methods differed with respect to mean TFBUTs (5.82 seconds, FS; 3.98 seconds, VCMA; P = 0.002). The FS variables alone (TFBUT, IBI) were not able to successfully distinguish between the dry-eye and normal subjects, whereas the additional VCMA variables, both derived and observed (BUA, BUA/IBI, breakup rate), were able to successfully distinguish between the dry-eye and normal subjects in a statistically significant fashion. TFBUT (P = 0.034) and BUA/IBI (P = 0.001) were able to distinguish the treatment effect of artificial tears in dry-eye subjects. Conclusion: The VCMA methodology provides a clinically relevant analysis of tear film stability measured in the context of a natural blink pattern.

AB - Purpose: To evaluate a new method of measuring ocular exposure in the context of a natural blink pattern through analysis of the variables tear film breakup time (TFBUT), interblink interval (IBI), and tear film breakup area (BUA). Methods: The traditional methodology (Forced-Stare [FS]) measures TFBUT and IBI separately. TFBUT is measured under forced-stare conditions by an examiner using a stopwatch, while IBI is measured as the subject watches television. The new methodology (video capture manual analysis [VCMA]) involves retrospective analysis of video data of fluorescein-stained eyes taken through a slit lamp while the subject watches television, and provides TFBUT and BUA for each IBI during the 1-minute video under natural blink conditions. The FS and VCMA methods were directly compared in the same set of dry-eye subjects. The VCMA method was evaluated for the ability to discriminate between dry-eye subjects and normal subjects. The VCMA method was further evaluated in the dry eye subjects for the ability to detect a treatment effect before, and 10 minutes after, bilateral instillation of an artificial tear solution. Results: Ten normal subjects and 17 dry-eye subjects were studied. In the dry-eye subjects, the two methods differed with respect to mean TFBUTs (5.82 seconds, FS; 3.98 seconds, VCMA; P = 0.002). The FS variables alone (TFBUT, IBI) were not able to successfully distinguish between the dry-eye and normal subjects, whereas the additional VCMA variables, both derived and observed (BUA, BUA/IBI, breakup rate), were able to successfully distinguish between the dry-eye and normal subjects in a statistically significant fashion. TFBUT (P = 0.034) and BUA/IBI (P = 0.001) were able to distinguish the treatment effect of artificial tears in dry-eye subjects. Conclusion: The VCMA methodology provides a clinically relevant analysis of tear film stability measured in the context of a natural blink pattern.

KW - Forced stare

KW - Interblink interval

KW - Ocular protection index

KW - Tear film breakup time

UR - http://www.scopus.com/inward/record.url?scp=81055125673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81055125673&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:81055125673

VL - 5

SP - 1349

EP - 1357

JO - Clinical Ophthalmology

JF - Clinical Ophthalmology

SN - 1177-5467

IS - 1

ER -