Mathematical analysis of the transmission dynamics of HIV/TB coinfection in the presence of treatment

Oluwaseun Sharomi, Chandra N. Podder, Abba Gumel, Baojun Song

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

This paper addresses the synergistic interaction between HIV and mycobacterium tuberculosis using a deterministic model, which incorporates many of the essential biological and epidemiological features of the two diseases. In the absence of TB infection, the model (IIIV-only model) is shown to have a globally asymptotically stable, disease-free equilibrium whenever the associated reproduction number is less than unity and has a unique endemic equilibrium whenever this number exceeds unity. On the other hand, the model with TB alone (TB-only model) undergoes the phenomenon of backward bifurcation, where the stable disease-free equilibrium co-exists with a stable endemic equilibrium when the associated reproduction threshold is less than unity. The analysis of the respective reproduction thresholds shows that the use of a targeted HIV treatment (using anti-retroviral drugs) strategy can lead to effective control of HIV provided it reduces the relative infectiousness of individuals treated (in comparison to untreated HIV-infected individuals) below a certain threshold. The full model, with both HIV and TB, is simulated to evaluate the impact of the various treatment strategies. It is shown that the HIV-only treatment strategy saves more cases of the mixed infection than the TB-only strategy. Further, for low treatment rates, the mixed-only strategy saves the least number of cases (of HIV, TB, and the mixed infection) in comparison to the other strategies. Thus, this study shows that if resources are limited, then targeting such resources to treating one of the diseases is more beneficial in reducing new cases of the mixed infection than targeting the mixed infection only diseases. Finally, the universal strategy saves more cases of the mixed infection than any of the other strategies.

Original languageEnglish (US)
Pages (from-to)145-174
Number of pages30
JournalMathematical Biosciences and Engineering
Volume5
Issue number1
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

Mathematical Analysis
Coinfection
mixed infection
HIV
Infection
Reproduction
Endemic Equilibrium
Mycobacterium tuberculosis
Backward Bifurcation
Reproduction number
Tuberculosis
Resources
Model
Strategy
Globally Asymptotically Stable
Deterministic Model
Drugs
Exceed
infection
Evaluate

Keywords

  • Bifurcation
  • Equilibria
  • HIV/TB
  • Stability
  • Treatment

ASJC Scopus subject areas

  • Applied Mathematics
  • Modeling and Simulation
  • Computational Mathematics
  • Agricultural and Biological Sciences(all)
  • Medicine(all)

Cite this

Mathematical analysis of the transmission dynamics of HIV/TB coinfection in the presence of treatment. / Sharomi, Oluwaseun; Podder, Chandra N.; Gumel, Abba; Song, Baojun.

In: Mathematical Biosciences and Engineering, Vol. 5, No. 1, 01.2008, p. 145-174.

Research output: Contribution to journalArticle

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