TY - JOUR
T1 - Mass spectrometry-based visualization of molecules associated with human habitats
AU - Petras, Daniel
AU - Nothias, Louis Félix
AU - Quinn, Robert A.
AU - Alexandrov, Theodore
AU - Bandeira, Nuno
AU - Bouslimani, Amina
AU - Castro-Falcón, Gabriel
AU - Chen, Liangyu
AU - Dang, Tam
AU - Floros, Dimitrios J.
AU - Hook, Vivian
AU - Garg, Neha
AU - Hoffner, Nicole
AU - Jiang, Yike
AU - Kapono, Clifford A.
AU - Koester, Irina
AU - Knight, Rob
AU - Leber, Christopher A.
AU - Ling, Tie Jun
AU - Luzzatto-Knaan, Tal
AU - McCall, Laura Isobel
AU - McGrath, Aaron P.
AU - Meehan, Michael J.
AU - Merritt, Jonathan K.
AU - Mills, Robert H.
AU - Morton, Jamie
AU - Podvin, Sonia
AU - Protsyuk, Ivan
AU - Purdy, Trevor
AU - Satterfield, Kendall
AU - Searles, Stephen
AU - Shah, Sahil
AU - Shires, Sarah
AU - Steffen, Dana
AU - White, Margot
AU - Todoric, Jelena
AU - Tuttle, Robert
AU - Wojnicz, Aneta
AU - Sapp, Valerie
AU - Vargas, Fernando
AU - Yang, Jin
AU - Zhang, Chao
AU - Dorrestein, Pieter C.
N1 - Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/11/15
Y1 - 2016/11/15
N2 - The cars we drive, the homes we live in, the restaurants we visit, and the laboratories and offices we work in are all a part of the modern human habitat. Remarkably, little is known about the diversity of chemicals present in these environments and to what degree molecules from our bodies influence the built environment that surrounds us and vice versa. We therefore set out to visualize the chemical diversity of five built human habitats together with their occupants, to provide a snapshot of the various molecules to which humans are exposed on a daily basis. The molecular inventory was obtained through untargeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of samples from each human habitat and from the people that occupy those habitats. Mapping MS-derived data onto 3D models of the environments showed that frequently touched surfaces, such as handles (e.g., door, bicycle), resemble the molecular fingerprint of the human skin more closely than other surfaces that are less frequently in direct contact with humans (e.g., wall, bicycle frame). Approximately 50% of the MS/MS spectra detected were shared between people and the environment. Personal care products, plasticizers, cleaning supplies, food, food additives, and even medications that were found to be a part of the human habitat. The annotations indicate that significant transfer of chemicals takes place between us and our built environment. The workflows applied here will lay the foundation for future studies of molecular distributions in medical, forensic, architectural, space exploration, and environmental applications.
AB - The cars we drive, the homes we live in, the restaurants we visit, and the laboratories and offices we work in are all a part of the modern human habitat. Remarkably, little is known about the diversity of chemicals present in these environments and to what degree molecules from our bodies influence the built environment that surrounds us and vice versa. We therefore set out to visualize the chemical diversity of five built human habitats together with their occupants, to provide a snapshot of the various molecules to which humans are exposed on a daily basis. The molecular inventory was obtained through untargeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of samples from each human habitat and from the people that occupy those habitats. Mapping MS-derived data onto 3D models of the environments showed that frequently touched surfaces, such as handles (e.g., door, bicycle), resemble the molecular fingerprint of the human skin more closely than other surfaces that are less frequently in direct contact with humans (e.g., wall, bicycle frame). Approximately 50% of the MS/MS spectra detected were shared between people and the environment. Personal care products, plasticizers, cleaning supplies, food, food additives, and even medications that were found to be a part of the human habitat. The annotations indicate that significant transfer of chemicals takes place between us and our built environment. The workflows applied here will lay the foundation for future studies of molecular distributions in medical, forensic, architectural, space exploration, and environmental applications.
UR - http://www.scopus.com/inward/record.url?scp=85044508304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044508304&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.6b03456
DO - 10.1021/acs.analchem.6b03456
M3 - Review article
C2 - 27732780
AN - SCOPUS:85044508304
SN - 0003-2700
VL - 88
SP - 10775
EP - 10784
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 22
ER -