Mass spectrometric immunoassay revisited

Randall W. Nelson, Chad Borges

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The progressive understanding and improvement of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS), realized over the years through the considerable efforts of Dr. Marvin Vestal, have made possible numerous comparable efforts involving its application in the biological sciences. Here we revisit the concepts behind one such analytical approach, Mass Spectrometric Immunoassay, which is designed to selectively detect and quantify proteins present in biological milieu.

Original languageEnglish (US)
Pages (from-to)960-968
Number of pages9
JournalJournal of the American Society for Mass Spectrometry
Volume22
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • Affinity capture
  • Clinical and Diagnostic Mass Spectrometry
  • MALDI-TOF
  • Marvin Vestal
  • Protein Quantification

ASJC Scopus subject areas

  • Structural Biology
  • Spectroscopy

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