Mass measurements of natural products by solution phase secondary ion mass spectrometry employing silver® and thallium® derivatives1-2

George Pettit, Cedric W. Holzapfel, Gordon M. Cragg

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The promotion and detection of molecular ions in the mass spectra of relatively simple to complex biosynthetic products, and a large cross-section of other compounds, has been simplified by employing silver or thallium(I) tetrafluoroborate in sulfolane for solution phase SIMS. The easily recognized isotope doublets of107Ag, 109Ag (52:49 natural abundance) and 203T1 205T1 (30:70) combined with the generally very strong [M + Ag]+ and [M+T1]+ molecular ion complex intensities provided powerful new techniques for mass measurements. Because the degree of molecular ion complex intensity was found to be a function of the specimens structure, application of these methods augmented by lithium and/or Nal or trifluoromethanesulfonic acid (for basic nitrogen containing compounds) was recommended for all new molecular weight determinations by mass spectrometry.

Original languageEnglish (US)
Pages (from-to)941-946
Number of pages6
JournalJournal of Natural Products
Volume47
Issue number6
DOIs
StatePublished - Jan 1984

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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