TY - JOUR
T1 - Markers of disease evolution
T2 - The case of tuberculosis
AU - Aparicio, Juan P.
AU - Capurro, Angel F.
AU - Castillo-Chavez, Carlos
N1 - Funding Information:
We thank Lisa Sattenspiel, Sally Blower, Baojun Song and two anonymous referees for their comments and suggestions. This work has been partially supported by NSF and NSA grants to the Mathematical and Theoretical Biology Institute at Cornell University, the office of the Provost of Cornell University and CONICET of Argentina.
PY - 2002
Y1 - 2002
N2 - Abrupt changes in environmental conditions - broadly understood to include demographic and social dynamics - can seriously impact the local or global disease dynamics of a population. These changes in the evolutionary landscape, which may occur over relatively short time-scales, are very likely to play a critical role in disease evolution. The potential impact of demographic, social and epidemiological shifts on the evolution of tuberculosis epidemics in the United States over the past century and a half is the main subject of this article. Evidence is provided to support the hypothesis that the observed substantial decreases in the incidence of active tuberculosis are the result of abrupt reductions in the rates of disease progression.
AB - Abrupt changes in environmental conditions - broadly understood to include demographic and social dynamics - can seriously impact the local or global disease dynamics of a population. These changes in the evolutionary landscape, which may occur over relatively short time-scales, are very likely to play a critical role in disease evolution. The potential impact of demographic, social and epidemiological shifts on the evolution of tuberculosis epidemics in the United States over the past century and a half is the main subject of this article. Evidence is provided to support the hypothesis that the observed substantial decreases in the incidence of active tuberculosis are the result of abrupt reductions in the rates of disease progression.
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U2 - 10.1006/jtbi.2001.2489
DO - 10.1006/jtbi.2001.2489
M3 - Article
C2 - 12051976
AN - SCOPUS:0036343338
SN - 0022-5193
VL - 215
SP - 227
EP - 237
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 2
ER -