Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase β

Shugeng Cao, Zhijie Gao, Shannon J. Thomas, Sidney M. Hecht, John S. Lazo, David G.I. Kingston

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2′-deoxyuridine. The structure of the new compound 1 was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.

Original languageEnglish (US)
Pages (from-to)1716-1718
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number10
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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