Abstract
fifteen year investigation of marine animal components as sources for new and potentially useful cancer chemotherapeutic drugs has led to our discovery of a number of such valuable substances. The especially productive Indian Ocean sea hare Dolabella auricularia has yielded (100 kg→~l mg each) a series of very potent cell growth inhibitory substances designated dolastatins 1-9. The first member of this new’ series, dolastatin 1, may represent the most potent anticancer agent so far uncovered with, e.g., a curative response (33%) using a dose of 11µg/kg (T/C 240, to T/C 139 at 1.37µg/kg) in the National Cancer Institute's murine B16 melanoma. Structural elucidation of the new antineoplastic agents is underway, and recent progress is illustrated with the peptide dolastatin 3 (P388 ED50 2.7 x 10-7µg/ml).
Original language | English (US) |
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Pages (from-to) | 482-485 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 44 |
Issue number | 4 |
DOIs | |
State | Published - Jul 1981 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry