Mapping of the human complement factor I gene to 4q25

Rita Shiang, Jeffrey C. Murray, Cynthia C. Morton, Kenneth H. Buetow, John J. Wasmuth, Ann Haskins Olney, Warren G. Sanger, Gabriel Goldberger

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids, in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25. The order GC-INP10-ADH3-EGF-IF-IL2-MNS is proposed for genes on 4q on the basis of genetic and physical mapping techniques. A BclI polymorphism found with the IF probe demonstrated a maternal origin for a de novo deletion of chromosome 4 that was used in physically mapping the gene. The genetic and physical distances around band 4q24 suggest that 1 cM is approximately 1.2 million bp of DNA. This work provides a useful addition to the map of 4q.

Original languageEnglish (US)
Pages (from-to)82-86
Number of pages5
JournalGenomics
Volume4
Issue number1
DOIs
StatePublished - Jan 1989
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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    Shiang, R., Murray, J. C., Morton, C. C., Buetow, K. H., Wasmuth, J. J., Olney, A. H., Sanger, W. G., & Goldberger, G. (1989). Mapping of the human complement factor I gene to 4q25. Genomics, 4(1), 82-86. https://doi.org/10.1016/0888-7543(89)90318-2