TY - GEN
T1 - Mapping abnormal subcortical brain morphometry in an elderly HIV+ cohort
AU - Wade, Benjamin S C
AU - Valcour, Victor G.
AU - Wendelken-Riegelhaupt, Lauren
AU - Esmaeili-Firidouni, Pardis
AU - Joshi, Shantanu H.
AU - Wang, Yalin
AU - Thompson, Paul M.
N1 - Publisher Copyright:
© 2015 IEEE.
PY - 2015/7/21
Y1 - 2015/7/21
N2 - Over 50% of HIV+ individuals exhibit neurocognitive impairment and subcortical atrophy, but the pattern of brain abnormalities associated with HIV is still poorly understood. Using parametric surface-based shape analyses, we mapped the 3D profile of subcortical morphometry in 63 HIV+ participants and 31 uninfected controls. The thalamus, corpus striatum, hippocampus, amygdala, brainstem, callosum and ventricles were segmented from brain MRIs. To investigate subcortical shape, we analyzed the Jacobian determinant (JD) and radial distances (RD) for structure surfaces. We also investigated effects of nadir CD4+ T-cell counts, viral load, and illness duration on subcortical morphology. Our results characterize subcortical morphometry in older HIV+ people, where participants showed significant volumetric enlargements in the thalamus, left pallidum and the ventricles while showing a reduction in the callosum. Further, RD maps revealed atrophy of the left thalamus and expansion of the brainstem in HIV. RD and JD maps of the right pallidum identified tissue expansion associated with illness duration while the left pallidum showed anterior atrophy and posterior expansion associated with viral load.
AB - Over 50% of HIV+ individuals exhibit neurocognitive impairment and subcortical atrophy, but the pattern of brain abnormalities associated with HIV is still poorly understood. Using parametric surface-based shape analyses, we mapped the 3D profile of subcortical morphometry in 63 HIV+ participants and 31 uninfected controls. The thalamus, corpus striatum, hippocampus, amygdala, brainstem, callosum and ventricles were segmented from brain MRIs. To investigate subcortical shape, we analyzed the Jacobian determinant (JD) and radial distances (RD) for structure surfaces. We also investigated effects of nadir CD4+ T-cell counts, viral load, and illness duration on subcortical morphology. Our results characterize subcortical morphometry in older HIV+ people, where participants showed significant volumetric enlargements in the thalamus, left pallidum and the ventricles while showing a reduction in the callosum. Further, RD maps revealed atrophy of the left thalamus and expansion of the brainstem in HIV. RD and JD maps of the right pallidum identified tissue expansion associated with illness duration while the left pallidum showed anterior atrophy and posterior expansion associated with viral load.
KW - HIV
KW - MRI
KW - classification
KW - random forest
KW - regularization
KW - shape analysis
KW - subcortical
UR - http://www.scopus.com/inward/record.url?scp=84944328352&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84944328352&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2015.7164033
DO - 10.1109/ISBI.2015.7164033
M3 - Conference contribution
AN - SCOPUS:84944328352
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 971
EP - 975
BT - 2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015
PB - IEEE Computer Society
T2 - 12th IEEE International Symposium on Biomedical Imaging, ISBI 2015
Y2 - 16 April 2015 through 19 April 2015
ER -