Abstract
Here we report a novel method for the manipulation and concentration of Aβ amyloid fibrils, implicated in Alzheimer's disease, using DC insulating gradient dielectrophoresis (DC-iGDEP). Fibril enrichment was found to be ∼400%. Simulations suggest that capture of the full range of amyloid protein aggregates is possible with optimized device design.
Original language | English (US) |
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Pages (from-to) | 3227-3229 |
Number of pages | 3 |
Journal | Analyst |
Volume | 137 |
Issue number | 14 |
DOIs | |
State | Published - Jul 21 2012 |
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Environmental Chemistry
- Spectroscopy
- Electrochemistry