Manipulation and capture of Aβ amyloid fibrils and monomers by DC insulator gradient dielectrophoresis (DC-iGDEP)

Sarah J R Staton, Paul V. Jones, Ginger Ku, S. Douglass Gilman, Indu Kheterpal, Mark Hayes

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Here we report a novel method for the manipulation and concentration of Aβ amyloid fibrils, implicated in Alzheimer's disease, using DC insulating gradient dielectrophoresis (DC-iGDEP). Fibril enrichment was found to be ∼400%. Simulations suggest that capture of the full range of amyloid protein aggregates is possible with optimized device design.

Original languageEnglish (US)
Pages (from-to)3227-3229
Number of pages3
JournalAnalyst
Volume137
Issue number14
DOIs
StatePublished - Jul 21 2012

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

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