TY - JOUR
T1 - Mangelnde körperliche Aktivität, neuropsychiatrische Symptome und das Risiko einer leichten kognitiven Beeinträchtigung bei älteren, in der Gemeinschaft lebenden Personen
T2 - Eine prospektive Kohortenstudie
AU - Krell-Roesch, Janina
AU - Syrjanen, Jeremy A.
AU - Bezold, Jelena
AU - Trautwein, Sandra
AU - Barisch-Fritz, Bettina
AU - Kremers, Walter K.
AU - Machulda, Mary M.
AU - Mielke, Michelle M.
AU - Knopman, David S.
AU - Petersen, Ronald C.
AU - Woll, Alexander
AU - Vassilaki, Maria
AU - Geda, Yonas E.
N1 - Funding Information:
Support for this research was provided by NIH grants: National Institute on Aging (R01 AG057708; U01 AG006786; P50 AG016574; R01 AG034676), and National Institute of Mental Health (K01 MH068351). This project was also supported by the Robert Wood Johnson Foundation, the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer’s Disease Research Program, the GHR Foundation, the Mayo Foundation for Medical Education and Research, the Edli Foundation, and the Arizona Alzheimer’s Consortium.
Funding Information:
W.K. Kremers receives research funding from the Department of Defense, NIH, Astra Zeneca, Biogen, and Roche. M.M. Machulda receives research funding from the NIH. M.M. Mielke served as a consultant to Eli Lilly, received unrestricted research grants from Biogen, Lundbeck, and Roche, and receives research funding from the NIA, NIH, and the Department of Defense. D.S. Knopman serves on a Data Safety Monitoring Board for the Dominantly Inherited Alzheimer Network (DIAN) study and is an investigator in clinical trials sponsored by Biogen, Lilly Pharmaceuticals, and the University of Southern California. R.C. Petersen consults for Roche Inc, Merck Inc, Genentech Inc, Eisai, Inc, Biogen Inc, and GE Healthcare and receives royalties from Oxford University Press for the publication of Mild Cognitive Impairment. M. Vassilaki received research funding from Roche, and currently receives research funding from NIH and Biogen. She has equity ownership in Abbott Laboratories, Johnson and Johnson, Medtronic, and Amgen. Y.E. Geda receives funding from the NIH and Roche and served on the Lundbeck Advisory Board. J. Krell-Roesch, J.A. Syrjanen, J. Bezold, S. Trautwein, B. Barisch-Fritz, and A. Woll declare that they have no competing interests.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - The present study examined the longitudinal association and interaction between lack of engaging in physical activity (PA) and presence of neuropsychiatric symptoms (NPS) with the risk of incident mild cognitive impairment (MCI). The authors conducted a prospective cohort study in the setting of the population-based Mayo Clinic Study of Aging in Minnesota, USA, involving 3083 cognitively unimpaired persons aged ≥ 50 years (1570 males; median age, 74 years). Predictors included: lack of engaging in light, moderate, and vigorous intensity PA within 1 year of baseline assessment as measured by a self-reported questionnaire; and presence of NPS (agitation, anxiety, apathy, appetite change, sleep/nighttime disturbance, depression, irritability, clinical depression, clinical anxiety) as measured by standardized tools. When the authors detected a statistically significant interaction, they compared the risk of incident MCI between four groups of participants (no NPS/engaging in PA = reference group; NPS/engaging in PA; no NPS/not engaging in PA; NPS/not engaging in PA) by calculating hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazard models adjusted for age (as time scale), sex, education, global cognition, medical comorbidities, and apolipoprotein E ɛ4 status. After a median follow-up of 6.3 years, 599 participants developed incident MCI. Not engaging in vigorous intensity PA and having sleep/nighttime disturbance (HR [95% CI], 1.61 [1.07, 2.43]; p = 0.021), clinical depression (1.98 [1.34, 2.92]; p < 0.001) or clinical anxiety (1.63 [1.11, 2.41]; p = 0.013) was associated with an increased risk of incident MCI as compared to the reference group. Thus, the combined presence of lack of vigorous intensity physical activity with sleep/nighttime disturbance behavior, clinical depression, or clinical anxiety was greater than the expected arithmetic sum of their independent effects. Neuropsychiatric symptoms appear to be a stronger driving force of incident MCI than lack of physical activity.
AB - The present study examined the longitudinal association and interaction between lack of engaging in physical activity (PA) and presence of neuropsychiatric symptoms (NPS) with the risk of incident mild cognitive impairment (MCI). The authors conducted a prospective cohort study in the setting of the population-based Mayo Clinic Study of Aging in Minnesota, USA, involving 3083 cognitively unimpaired persons aged ≥ 50 years (1570 males; median age, 74 years). Predictors included: lack of engaging in light, moderate, and vigorous intensity PA within 1 year of baseline assessment as measured by a self-reported questionnaire; and presence of NPS (agitation, anxiety, apathy, appetite change, sleep/nighttime disturbance, depression, irritability, clinical depression, clinical anxiety) as measured by standardized tools. When the authors detected a statistically significant interaction, they compared the risk of incident MCI between four groups of participants (no NPS/engaging in PA = reference group; NPS/engaging in PA; no NPS/not engaging in PA; NPS/not engaging in PA) by calculating hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazard models adjusted for age (as time scale), sex, education, global cognition, medical comorbidities, and apolipoprotein E ɛ4 status. After a median follow-up of 6.3 years, 599 participants developed incident MCI. Not engaging in vigorous intensity PA and having sleep/nighttime disturbance (HR [95% CI], 1.61 [1.07, 2.43]; p = 0.021), clinical depression (1.98 [1.34, 2.92]; p < 0.001) or clinical anxiety (1.63 [1.11, 2.41]; p = 0.013) was associated with an increased risk of incident MCI as compared to the reference group. Thus, the combined presence of lack of vigorous intensity physical activity with sleep/nighttime disturbance behavior, clinical depression, or clinical anxiety was greater than the expected arithmetic sum of their independent effects. Neuropsychiatric symptoms appear to be a stronger driving force of incident MCI than lack of physical activity.
KW - Anxiety
KW - Cognition
KW - Depression
KW - Lifestyle
KW - Longitudinal
UR - http://www.scopus.com/inward/record.url?scp=85111301681&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85111301681&partnerID=8YFLogxK
U2 - 10.1007/s12662-021-00732-8
DO - 10.1007/s12662-021-00732-8
M3 - Article
AN - SCOPUS:85111301681
SN - 2509-3142
VL - 51
SP - 487
EP - 494
JO - German Journal of Exercise and Sport Research
JF - German Journal of Exercise and Sport Research
IS - 4
ER -