TY - JOUR
T1 - Malaria evolution in South Asia
T2 - Knowledge for control and elimination
AU - Narayanasamy, Krishnamoorthy
AU - Chery, Laura
AU - Basu, Analabha
AU - Duraisingh, Manoj T.
AU - Escalante, Ananias
AU - Fowble, Joseph
AU - Guler, Jennifer L.
AU - Herricks, Thurston
AU - Kumar, Ashwani
AU - Majumder, Partha
AU - Maki, Jennifer
AU - Mascarenhas, Anjali
AU - Rodrigues, Janneth
AU - Roy, Bikram
AU - Sen, Somdutta
AU - Shastri, Jayanthi
AU - Smith, Joseph
AU - Valecha, Neena
AU - White, John
AU - Rathod, Pradipsinh K.
N1 - Funding Information:
The Program Project on “Malaria Evolution in South Asia” is an International Center of Excellence for Malaria Research (ICEMR) supported by the US National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIH/NIAID) grant U19 AI089688.
PY - 2012/3
Y1 - 2012/3
N2 - The study of malaria parasites on the Indian subcontinent should help us understand unexpected disease outbreaks and unpredictable disease presentations from Plasmodium falciparum and Plasmodium vivax infections. The Malaria Evolution in South Asia (MESA) research program is one of ten International Centers of Excellence for Malaria Research (ICEMR) sponsored by the US National Institutes of Health. In this second of two reviews, we describe why population structures of Plasmodia in India will be characterized and how we will determine their consequences on disease presentation, outcome and patterns. Specific projects will determine if genetic diversity, possibly driven by parasites with higher genetic plasticity, plays a role in changing epidemiology, pathogenesis, vector competence of parasite populations and whether innate human genetic traits protect Indians from malaria today. Deep local clinical knowledge of malaria in India will be supplemented by basic scientists who bring new research tools. Such tools will include whole genome sequencing and analysis methods; in vitro assays to measure genome plasticity, RBC cytoadhesion, invasion, and deformability; mosquito infectivity assays to evaluate changing parasite-vector compatibilities; and host genetics to understand protective traits in Indian populations. The MESA-ICEMR study sites span diagonally across India and include a mixture of very urban and rural hospitals, each with very different disease patterns and patient populations. Research partnerships include government-associated research institutes, private medical schools, city and state government hospitals, and hospitals with industry ties. Between 2012 and 2017, in addition to developing clinical research and basic science infrastructure at new clinical sites, our training workshops will engage new scientists and clinicians throughout South Asia in the malaria research field.
AB - The study of malaria parasites on the Indian subcontinent should help us understand unexpected disease outbreaks and unpredictable disease presentations from Plasmodium falciparum and Plasmodium vivax infections. The Malaria Evolution in South Asia (MESA) research program is one of ten International Centers of Excellence for Malaria Research (ICEMR) sponsored by the US National Institutes of Health. In this second of two reviews, we describe why population structures of Plasmodia in India will be characterized and how we will determine their consequences on disease presentation, outcome and patterns. Specific projects will determine if genetic diversity, possibly driven by parasites with higher genetic plasticity, plays a role in changing epidemiology, pathogenesis, vector competence of parasite populations and whether innate human genetic traits protect Indians from malaria today. Deep local clinical knowledge of malaria in India will be supplemented by basic scientists who bring new research tools. Such tools will include whole genome sequencing and analysis methods; in vitro assays to measure genome plasticity, RBC cytoadhesion, invasion, and deformability; mosquito infectivity assays to evaluate changing parasite-vector compatibilities; and host genetics to understand protective traits in Indian populations. The MESA-ICEMR study sites span diagonally across India and include a mixture of very urban and rural hospitals, each with very different disease patterns and patient populations. Research partnerships include government-associated research institutes, private medical schools, city and state government hospitals, and hospitals with industry ties. Between 2012 and 2017, in addition to developing clinical research and basic science infrastructure at new clinical sites, our training workshops will engage new scientists and clinicians throughout South Asia in the malaria research field.
KW - Drug resistance
KW - Epidemiology
KW - ICEMR
KW - India
KW - Malaria
KW - Plasmodium falciparum
KW - Plasmodium vivax
KW - South Asia
UR - http://www.scopus.com/inward/record.url?scp=84862831616&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862831616&partnerID=8YFLogxK
U2 - 10.1016/j.actatropica.2012.01.008
DO - 10.1016/j.actatropica.2012.01.008
M3 - Article
C2 - 22266213
AN - SCOPUS:84862831616
VL - 121
SP - 256
EP - 266
JO - Acta Tropica
JF - Acta Tropica
SN - 0001-706X
IS - 3
ER -