Major histocompatibility complex differentiation in Sacramento River chinook salmon

Timothy J. Kim, Karen M. Parker, Philip W. Hedrick

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

The chinook salmon of the Sacramento River, California, have been reduced to a fraction of their former abundance because of human impact and use of the river system. Here we examine the genetic variation at a major histocompatibility complex class II exon in the four Sacramento chinook salmon runs. Examination of the alleles found in these and other chinook salmon revealed nucleotide patterns consistent with selection for amino acid replacement at the putative antigen-binding sites. We found a significant amount of variation in each of the runs, including the federally endangered winter run. All of the samples were in Hardy-Weinberg proportions. A significant amount of genetic differentiation between runs was revealed by several measures of differentiation. Winter run was the most genetically divergent, while the spring, late-fall, and fall runs were less differentiated.

Original languageEnglish (US)
Pages (from-to)1115-1122
Number of pages8
JournalGenetics
Volume151
Issue number3
StatePublished - Mar 1 1999

ASJC Scopus subject areas

  • Genetics

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