Macroporous nanowire nanoelectronic scaffolds for synthetic tissues

Bozhi Tian, Jia Liu, Tal Dvir, Lihua Jin, Jonathan H. Tsui, Quan Qing, Zhigang Suo, Robert Langer, Daniel S. Kohane, Charles M. Lieber

Research output: Contribution to journalArticle

356 Citations (Scopus)

Abstract

The development of three-dimensional (3D) synthetic biomaterials as structural and bioactive scaffolds is central to fields ranging from cellular biophysics to regenerative medicine. As of yet, these scaffolds cannot electrically probe the physicochemical and biological microenvironments throughout their 3D and macroporous interior, although this capability could have a marked impact in both electronics and biomaterials. Here, we address this challenge using macroporous, flexible and free-standing nanowire nanoelectronic scaffolds (nanoES), and their hybrids with synthetic or natural biomaterials. 3D macroporous nanoES mimic the structure of natural tissue scaffolds, and they were formed by self-organization of coplanar reticular networks with built-in strain and by manipulation of 2D mesh matrices. NanoES exhibited robust electronic properties and have been used alone or combined with other biomaterials as biocompatible extracellular scaffolds for 3D culture of neurons, cardiomyocytes and smooth muscle cells. Furthermore, we show the integrated sensory capability of the nanoES by real-time monitoring of the local electrical activity within 3D nanoES/cardiomyocyte constructs, the response of 3D-nanoES-based neural and cardiac tissue models to drugs, and distinct pH changes inside and outside tubular vascular smooth muscle constructs.

Original languageEnglish (US)
Pages (from-to)986-994
Number of pages9
JournalNature Materials
Volume11
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

Fingerprint

smooth muscle
Nanoelectronics
Biocompatible Materials
muscles
Biomaterials
Scaffolds
Nanowires
nanowires
Tissue
biophysics
muscle cells
Scaffolds (biology)
activity (biology)
neurons
medicine
electronics
Muscle
manipulators
mesh
drugs

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Condensed Matter Physics
  • Materials Science(all)
  • Chemistry(all)

Cite this

Tian, B., Liu, J., Dvir, T., Jin, L., Tsui, J. H., Qing, Q., ... Lieber, C. M. (2012). Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nature Materials, 11(11), 986-994. https://doi.org/10.1038/nmat3404

Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. / Tian, Bozhi; Liu, Jia; Dvir, Tal; Jin, Lihua; Tsui, Jonathan H.; Qing, Quan; Suo, Zhigang; Langer, Robert; Kohane, Daniel S.; Lieber, Charles M.

In: Nature Materials, Vol. 11, No. 11, 11.2012, p. 986-994.

Research output: Contribution to journalArticle

Tian, B, Liu, J, Dvir, T, Jin, L, Tsui, JH, Qing, Q, Suo, Z, Langer, R, Kohane, DS & Lieber, CM 2012, 'Macroporous nanowire nanoelectronic scaffolds for synthetic tissues', Nature Materials, vol. 11, no. 11, pp. 986-994. https://doi.org/10.1038/nmat3404
Tian, Bozhi ; Liu, Jia ; Dvir, Tal ; Jin, Lihua ; Tsui, Jonathan H. ; Qing, Quan ; Suo, Zhigang ; Langer, Robert ; Kohane, Daniel S. ; Lieber, Charles M. / Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. In: Nature Materials. 2012 ; Vol. 11, No. 11. pp. 986-994.
@article{b6f5878b93674ed08ca5c495525c116d,
title = "Macroporous nanowire nanoelectronic scaffolds for synthetic tissues",
abstract = "The development of three-dimensional (3D) synthetic biomaterials as structural and bioactive scaffolds is central to fields ranging from cellular biophysics to regenerative medicine. As of yet, these scaffolds cannot electrically probe the physicochemical and biological microenvironments throughout their 3D and macroporous interior, although this capability could have a marked impact in both electronics and biomaterials. Here, we address this challenge using macroporous, flexible and free-standing nanowire nanoelectronic scaffolds (nanoES), and their hybrids with synthetic or natural biomaterials. 3D macroporous nanoES mimic the structure of natural tissue scaffolds, and they were formed by self-organization of coplanar reticular networks with built-in strain and by manipulation of 2D mesh matrices. NanoES exhibited robust electronic properties and have been used alone or combined with other biomaterials as biocompatible extracellular scaffolds for 3D culture of neurons, cardiomyocytes and smooth muscle cells. Furthermore, we show the integrated sensory capability of the nanoES by real-time monitoring of the local electrical activity within 3D nanoES/cardiomyocyte constructs, the response of 3D-nanoES-based neural and cardiac tissue models to drugs, and distinct pH changes inside and outside tubular vascular smooth muscle constructs.",
author = "Bozhi Tian and Jia Liu and Tal Dvir and Lihua Jin and Tsui, {Jonathan H.} and Quan Qing and Zhigang Suo and Robert Langer and Kohane, {Daniel S.} and Lieber, {Charles M.}",
year = "2012",
month = "11",
doi = "10.1038/nmat3404",
language = "English (US)",
volume = "11",
pages = "986--994",
journal = "Nature Materials",
issn = "1476-1122",
publisher = "Nature Publishing Group",
number = "11",

}

TY - JOUR

T1 - Macroporous nanowire nanoelectronic scaffolds for synthetic tissues

AU - Tian, Bozhi

AU - Liu, Jia

AU - Dvir, Tal

AU - Jin, Lihua

AU - Tsui, Jonathan H.

AU - Qing, Quan

AU - Suo, Zhigang

AU - Langer, Robert

AU - Kohane, Daniel S.

AU - Lieber, Charles M.

PY - 2012/11

Y1 - 2012/11

N2 - The development of three-dimensional (3D) synthetic biomaterials as structural and bioactive scaffolds is central to fields ranging from cellular biophysics to regenerative medicine. As of yet, these scaffolds cannot electrically probe the physicochemical and biological microenvironments throughout their 3D and macroporous interior, although this capability could have a marked impact in both electronics and biomaterials. Here, we address this challenge using macroporous, flexible and free-standing nanowire nanoelectronic scaffolds (nanoES), and their hybrids with synthetic or natural biomaterials. 3D macroporous nanoES mimic the structure of natural tissue scaffolds, and they were formed by self-organization of coplanar reticular networks with built-in strain and by manipulation of 2D mesh matrices. NanoES exhibited robust electronic properties and have been used alone or combined with other biomaterials as biocompatible extracellular scaffolds for 3D culture of neurons, cardiomyocytes and smooth muscle cells. Furthermore, we show the integrated sensory capability of the nanoES by real-time monitoring of the local electrical activity within 3D nanoES/cardiomyocyte constructs, the response of 3D-nanoES-based neural and cardiac tissue models to drugs, and distinct pH changes inside and outside tubular vascular smooth muscle constructs.

AB - The development of three-dimensional (3D) synthetic biomaterials as structural and bioactive scaffolds is central to fields ranging from cellular biophysics to regenerative medicine. As of yet, these scaffolds cannot electrically probe the physicochemical and biological microenvironments throughout their 3D and macroporous interior, although this capability could have a marked impact in both electronics and biomaterials. Here, we address this challenge using macroporous, flexible and free-standing nanowire nanoelectronic scaffolds (nanoES), and their hybrids with synthetic or natural biomaterials. 3D macroporous nanoES mimic the structure of natural tissue scaffolds, and they were formed by self-organization of coplanar reticular networks with built-in strain and by manipulation of 2D mesh matrices. NanoES exhibited robust electronic properties and have been used alone or combined with other biomaterials as biocompatible extracellular scaffolds for 3D culture of neurons, cardiomyocytes and smooth muscle cells. Furthermore, we show the integrated sensory capability of the nanoES by real-time monitoring of the local electrical activity within 3D nanoES/cardiomyocyte constructs, the response of 3D-nanoES-based neural and cardiac tissue models to drugs, and distinct pH changes inside and outside tubular vascular smooth muscle constructs.

UR - http://www.scopus.com/inward/record.url?scp=84867888184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867888184&partnerID=8YFLogxK

U2 - 10.1038/nmat3404

DO - 10.1038/nmat3404

M3 - Article

VL - 11

SP - 986

EP - 994

JO - Nature Materials

JF - Nature Materials

SN - 1476-1122

IS - 11

ER -