Macroporous nanowire nanoelectronic scaffolds for synthetic tissues

Bozhi Tian, Jia Liu, Tal Dvir, Lihua Jin, Jonathan H. Tsui, Quan Qing, Zhigang Suo, Robert Langer, Daniel S. Kohane, Charles M. Lieber

Research output: Contribution to journalArticle

390 Scopus citations

Abstract

The development of three-dimensional (3D) synthetic biomaterials as structural and bioactive scaffolds is central to fields ranging from cellular biophysics to regenerative medicine. As of yet, these scaffolds cannot electrically probe the physicochemical and biological microenvironments throughout their 3D and macroporous interior, although this capability could have a marked impact in both electronics and biomaterials. Here, we address this challenge using macroporous, flexible and free-standing nanowire nanoelectronic scaffolds (nanoES), and their hybrids with synthetic or natural biomaterials. 3D macroporous nanoES mimic the structure of natural tissue scaffolds, and they were formed by self-organization of coplanar reticular networks with built-in strain and by manipulation of 2D mesh matrices. NanoES exhibited robust electronic properties and have been used alone or combined with other biomaterials as biocompatible extracellular scaffolds for 3D culture of neurons, cardiomyocytes and smooth muscle cells. Furthermore, we show the integrated sensory capability of the nanoES by real-time monitoring of the local electrical activity within 3D nanoES/cardiomyocyte constructs, the response of 3D-nanoES-based neural and cardiac tissue models to drugs, and distinct pH changes inside and outside tubular vascular smooth muscle constructs.

Original languageEnglish (US)
Pages (from-to)986-994
Number of pages9
JournalNature materials
Volume11
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Tian, B., Liu, J., Dvir, T., Jin, L., Tsui, J. H., Qing, Q., Suo, Z., Langer, R., Kohane, D. S., & Lieber, C. M. (2012). Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nature materials, 11(11), 986-994. https://doi.org/10.1038/nmat3404