Macrophage activating effects of new alkamides from the roots of Echinacea species

Ying Chen, Tong Fu, Tao Tao, Jinghua Yang, Yung Chang, Meihua Wang, Linda Kim, Luping Qu, John Cassady, Ric Scalzo, Xiping Wang

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Chemical investigation of the roots of Echinacea angustifolia, E. purpurea, and E. pallida yielded two new alkamides, identified by analysis of spectroscopic data and comparison with reported alkamides. The new compounds were dodeca-2Z,4E,10Z-trien-8-ynoic acid isobutylamide (1) from E. angustifolia and dodeca-2Z,4E-diene-8,10-diynoic acid isobutylamide (2) from E. purpurea and E. pallida. These two components, as well as previously identified alkamides, exerted inhibition on LPS-mediated activation of a murine macrophage line, RAW264.7. These data suggest that these alkamides may have anti-inflammatory activity. The cytotoxicity of these alkamides using MTT assays was also investigated.

Original languageEnglish (US)
Pages (from-to)773-776
Number of pages4
JournalJournal of Natural Products
Volume68
Issue number5
DOIs
StatePublished - May 2005

Fingerprint

Echinacea
Macrophages
Cytotoxicity
amides
Assays
macrophages
Anti-Inflammatory Agents
Chemical activation
Echinacea angustifolia
Echinacea pallida
Echinacea purpurea
acids
anti-inflammatory activity
cytotoxicity
data analysis
dodeca-2Z,4E,10Z-trien-8-ynoic acid isobutylamide
dodeca-2Z,4E-diene-8,10-diynoic acid isobutylamide
mice
assays

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Macrophage activating effects of new alkamides from the roots of Echinacea species. / Chen, Ying; Fu, Tong; Tao, Tao; Yang, Jinghua; Chang, Yung; Wang, Meihua; Kim, Linda; Qu, Luping; Cassady, John; Scalzo, Ric; Wang, Xiping.

In: Journal of Natural Products, Vol. 68, No. 5, 05.2005, p. 773-776.

Research output: Contribution to journalArticle

Chen, Y, Fu, T, Tao, T, Yang, J, Chang, Y, Wang, M, Kim, L, Qu, L, Cassady, J, Scalzo, R & Wang, X 2005, 'Macrophage activating effects of new alkamides from the roots of Echinacea species', Journal of Natural Products, vol. 68, no. 5, pp. 773-776. https://doi.org/10.1021/np040245f
Chen, Ying ; Fu, Tong ; Tao, Tao ; Yang, Jinghua ; Chang, Yung ; Wang, Meihua ; Kim, Linda ; Qu, Luping ; Cassady, John ; Scalzo, Ric ; Wang, Xiping. / Macrophage activating effects of new alkamides from the roots of Echinacea species. In: Journal of Natural Products. 2005 ; Vol. 68, No. 5. pp. 773-776.
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