Macrophage activating effects of new alkamides from the roots of Echinacea species

Ying Chen; Tong Fu; Tao Tao; Jinghua Yang; Yung Chang; Meihua Wang; Linda Kim; Luping Qu; John Cassady; Ric Scalzo; Xiping Wang

doi:10.1021/np040245f

Macrophage activating effects of new alkamides from the roots of Echinacea species

Ying Chen, Tong Fu, Tao Tao, Jinghua Yang, Yung Chang, Meihua Wang, Linda Kim, Luping Qu, John Cassady, Ric Scalzo, Xiping Wang

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Chemical investigation of the roots of Echinacea angustifolia, E. purpurea, and E. pallida yielded two new alkamides, identified by analysis of spectroscopic data and comparison with reported alkamides. The new compounds were dodeca-2Z,4E,10Z-trien-8-ynoic acid isobutylamide (1) from E. angustifolia and dodeca-2Z,4E-diene-8,10-diynoic acid isobutylamide (2) from E. purpurea and E. pallida. These two components, as well as previously identified alkamides, exerted inhibition on LPS-mediated activation of a murine macrophage line, RAW264.7. These data suggest that these alkamides may have anti-inflammatory activity. The cytotoxicity of these alkamides using MTT assays was also investigated.

Original language	English (US)
Pages (from-to)	773-776
Number of pages	4
Journal	Journal of Natural Products
Volume	68
Issue number	5
DOIs	https://doi.org/10.1021/np040245f
State	Published - May 2005

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np040245f

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title = "Macrophage activating effects of new alkamides from the roots of Echinacea species",

abstract = "Chemical investigation of the roots of Echinacea angustifolia, E. purpurea, and E. pallida yielded two new alkamides, identified by analysis of spectroscopic data and comparison with reported alkamides. The new compounds were dodeca-2Z,4E,10Z-trien-8-ynoic acid isobutylamide (1) from E. angustifolia and dodeca-2Z,4E-diene-8,10-diynoic acid isobutylamide (2) from E. purpurea and E. pallida. These two components, as well as previously identified alkamides, exerted inhibition on LPS-mediated activation of a murine macrophage line, RAW264.7. These data suggest that these alkamides may have anti-inflammatory activity. The cytotoxicity of these alkamides using MTT assays was also investigated.",

author = "Ying Chen and Tong Fu and Tao Tao and Jinghua Yang and Yung Chang and Meihua Wang and Linda Kim and Luping Qu and John Cassady and Ric Scalzo and Xiping Wang",

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AU - Chen, Ying

AU - Fu, Tong

AU - Tao, Tao

AU - Yang, Jinghua

AU - Chang, Yung

AU - Wang, Meihua

AU - Kim, Linda

AU - Qu, Luping

AU - Cassady, John

AU - Scalzo, Ric

AU - Wang, Xiping

PY - 2005/5

Y1 - 2005/5

N2 - Chemical investigation of the roots of Echinacea angustifolia, E. purpurea, and E. pallida yielded two new alkamides, identified by analysis of spectroscopic data and comparison with reported alkamides. The new compounds were dodeca-2Z,4E,10Z-trien-8-ynoic acid isobutylamide (1) from E. angustifolia and dodeca-2Z,4E-diene-8,10-diynoic acid isobutylamide (2) from E. purpurea and E. pallida. These two components, as well as previously identified alkamides, exerted inhibition on LPS-mediated activation of a murine macrophage line, RAW264.7. These data suggest that these alkamides may have anti-inflammatory activity. The cytotoxicity of these alkamides using MTT assays was also investigated.

AB - Chemical investigation of the roots of Echinacea angustifolia, E. purpurea, and E. pallida yielded two new alkamides, identified by analysis of spectroscopic data and comparison with reported alkamides. The new compounds were dodeca-2Z,4E,10Z-trien-8-ynoic acid isobutylamide (1) from E. angustifolia and dodeca-2Z,4E-diene-8,10-diynoic acid isobutylamide (2) from E. purpurea and E. pallida. These two components, as well as previously identified alkamides, exerted inhibition on LPS-mediated activation of a murine macrophage line, RAW264.7. These data suggest that these alkamides may have anti-inflammatory activity. The cytotoxicity of these alkamides using MTT assays was also investigated.

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Macrophage activating effects of new alkamides from the roots of Echinacea species

Abstract

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