MAb Therapeutics against West Nile Virus with Improved CNS Penetration

Qiang Chen (Inventor)

Research output: Patent

Abstract

West Nile virus (WNV), a member of the Flavivirus genus, can cause severe neurological disease, long-term morbidity, and death. In the last decade, nearly 30,000 cases of severe WNV infection have been diagnosed in the U.S. Historically, there has been a lack of effective and specific antiviral treatment for flavivirus infection; current treatment for WNV is supportive and no vaccine or therapeutic agent has been approved for human use. A promising humanized murine Mab (monoclonal antibody) mHu-E16 therapeutic candidate is in Phase II clinical trials, but since it does not cross the blood-brain barrier (BBB), it has a limited window of efficacy. Researchers at the Biodesign Institute of Arizona State University have built upon their earlier success (AzTE Case # M10-092) developing a plant-derived Hu-E16 antibody that has inhibitory activity indistinguishable from mammalian cell-produced mHu-E16. This new innovation is a bifunctional form of Hu-E16 that additionally binds receptors of endothelial cells of the BBB, allowing this antibody to rapidly penetrate the CNS and accumulate in concentrations sufficient for neutralizing the infecting WNV. This plant-derived Mab has the potential to provide greater efficacy and an enhanced treatment window compared to mammalian cell-produced versions, while being less expensive to produce and more scalable to industrial production. Potential Applications therapeutic for West Nile virus infection possible prophylactic vaccine for West Nile virus Benefits and Advantages readily crosses the blood-brain barrier for improved CNS penetration and better treatment efficacy extended treatment window Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. Lai's directory webpage Dr. Chen's directory webpage
Original languageEnglish (US)
StatePublished - Jan 7 2011

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West Nile virus
Blood-Brain Barrier
Directories
Virus Diseases
Plantibodies
West Nile Virus Vaccines
Flavivirus Infections
Therapeutics
Inventors
Antibodies, Monoclonal, Humanized
Flavivirus
Phase II Clinical Trials
Antibodies
Antiviral Agents
Vaccines
Endothelial Cells
Monoclonal Antibodies
Research Personnel
Morbidity
Research

Cite this

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title = "MAb Therapeutics against West Nile Virus with Improved CNS Penetration",
abstract = "West Nile virus (WNV), a member of the Flavivirus genus, can cause severe neurological disease, long-term morbidity, and death. In the last decade, nearly 30,000 cases of severe WNV infection have been diagnosed in the U.S. Historically, there has been a lack of effective and specific antiviral treatment for flavivirus infection; current treatment for WNV is supportive and no vaccine or therapeutic agent has been approved for human use. A promising humanized murine Mab (monoclonal antibody) mHu-E16 therapeutic candidate is in Phase II clinical trials, but since it does not cross the blood-brain barrier (BBB), it has a limited window of efficacy. Researchers at the Biodesign Institute of Arizona State University have built upon their earlier success (AzTE Case # M10-092) developing a plant-derived Hu-E16 antibody that has inhibitory activity indistinguishable from mammalian cell-produced mHu-E16. This new innovation is a bifunctional form of Hu-E16 that additionally binds receptors of endothelial cells of the BBB, allowing this antibody to rapidly penetrate the CNS and accumulate in concentrations sufficient for neutralizing the infecting WNV. This plant-derived Mab has the potential to provide greater efficacy and an enhanced treatment window compared to mammalian cell-produced versions, while being less expensive to produce and more scalable to industrial production. Potential Applications therapeutic for West Nile virus infection possible prophylactic vaccine for West Nile virus Benefits and Advantages readily crosses the blood-brain barrier for improved CNS penetration and better treatment efficacy extended treatment window Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. Lai's directory webpage Dr. Chen's directory webpage",
author = "Qiang Chen",
year = "2011",
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day = "7",
language = "English (US)",
type = "Patent",

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TY - PAT

T1 - MAb Therapeutics against West Nile Virus with Improved CNS Penetration

AU - Chen, Qiang

PY - 2011/1/7

Y1 - 2011/1/7

N2 - West Nile virus (WNV), a member of the Flavivirus genus, can cause severe neurological disease, long-term morbidity, and death. In the last decade, nearly 30,000 cases of severe WNV infection have been diagnosed in the U.S. Historically, there has been a lack of effective and specific antiviral treatment for flavivirus infection; current treatment for WNV is supportive and no vaccine or therapeutic agent has been approved for human use. A promising humanized murine Mab (monoclonal antibody) mHu-E16 therapeutic candidate is in Phase II clinical trials, but since it does not cross the blood-brain barrier (BBB), it has a limited window of efficacy. Researchers at the Biodesign Institute of Arizona State University have built upon their earlier success (AzTE Case # M10-092) developing a plant-derived Hu-E16 antibody that has inhibitory activity indistinguishable from mammalian cell-produced mHu-E16. This new innovation is a bifunctional form of Hu-E16 that additionally binds receptors of endothelial cells of the BBB, allowing this antibody to rapidly penetrate the CNS and accumulate in concentrations sufficient for neutralizing the infecting WNV. This plant-derived Mab has the potential to provide greater efficacy and an enhanced treatment window compared to mammalian cell-produced versions, while being less expensive to produce and more scalable to industrial production. Potential Applications therapeutic for West Nile virus infection possible prophylactic vaccine for West Nile virus Benefits and Advantages readily crosses the blood-brain barrier for improved CNS penetration and better treatment efficacy extended treatment window Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. Lai's directory webpage Dr. Chen's directory webpage

AB - West Nile virus (WNV), a member of the Flavivirus genus, can cause severe neurological disease, long-term morbidity, and death. In the last decade, nearly 30,000 cases of severe WNV infection have been diagnosed in the U.S. Historically, there has been a lack of effective and specific antiviral treatment for flavivirus infection; current treatment for WNV is supportive and no vaccine or therapeutic agent has been approved for human use. A promising humanized murine Mab (monoclonal antibody) mHu-E16 therapeutic candidate is in Phase II clinical trials, but since it does not cross the blood-brain barrier (BBB), it has a limited window of efficacy. Researchers at the Biodesign Institute of Arizona State University have built upon their earlier success (AzTE Case # M10-092) developing a plant-derived Hu-E16 antibody that has inhibitory activity indistinguishable from mammalian cell-produced mHu-E16. This new innovation is a bifunctional form of Hu-E16 that additionally binds receptors of endothelial cells of the BBB, allowing this antibody to rapidly penetrate the CNS and accumulate in concentrations sufficient for neutralizing the infecting WNV. This plant-derived Mab has the potential to provide greater efficacy and an enhanced treatment window compared to mammalian cell-produced versions, while being less expensive to produce and more scalable to industrial production. Potential Applications therapeutic for West Nile virus infection possible prophylactic vaccine for West Nile virus Benefits and Advantages readily crosses the blood-brain barrier for improved CNS penetration and better treatment efficacy extended treatment window Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. Lai's directory webpage Dr. Chen's directory webpage

M3 - Patent

ER -