M-T2: A poxvirus TNF receptor homologue with dual activities

Lisa Sedger, Grant McFadden

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Poxviruses are experts at manipulating and evading the host's immune response. They have acquired a number of open reading frames which specifically confer direct anti-immune properties, either by mimicking cytokine receptors and growth factors or by disarming cytokine regulatory cascades. The Myxoma T2 protein (M-T2), a TNF receptor homologue, is secreted from virus infected cells and can bind TNF-α with high affinity, and thereby inhibit TNF-α-mediated cytotoxicity. M-T2 also acts to inhibit virus-induced lymphocyte apoptosis by an as yet undefined mechanism. As such, T2 constitutes a significant virulence factor for poxviruses, influencing the outcome of infection, both in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)538-545
Number of pages8
JournalImmunology and Cell Biology
Volume74
Issue number6
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Keywords

  • TNF
  • TNF receptor superfamily
  • apoptosis
  • immune modifiers
  • poxvirus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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