Lymphocyte subsets in primary sclerosing cholangitis

Keith Lindor, Russell H. Wiesner, Jerry A. Katzmann, Nicholas F. Larusso, Sandra J. Beaver

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

As an initial step in testing the hypothesis that immunoregulatory abnormalities are important in the pathogenesis of primary sclerosing cholangitis, we determined the number and percentage of lymphocyte subsets in the peripheral blood of 33 patients with primary sclerosing cholangitis. In these patients, when compared with normal and diseased controls, there was a significant reduction in the total number of circulating T cells because of a disproportionate decrease in Leu-2a (suppressor/cytotoxic) cells. This decrease resulted in a significantly increased ratio of Leu-3a to Leu-2a cells. Patients with cirrhosis had significantly higher Leu-3a/Leu-2a (helper/suppressor) ratios than did noncirrhotic patients; both disease groups, however, had ratios that were significantly higher than controls. The number and percentage of B cells were significantly increased. Alterations in the percentage of B cells correlated significantly with histologic stage and concentrations of gamma globulin, serum IgG, and bilirubin. We conclude that these abnormalities are suggestive of a defect in immunoregulation in primary sclerosing cholangitis, which is not secondary to advanced liver disease alone and appears to be independent of chronic ulcerative colitis,or obstructive jaundice.

Original languageEnglish (US)
Pages (from-to)720-725
Number of pages6
JournalDigestive Diseases and Sciences
Volume32
Issue number7
DOIs
StatePublished - Jul 1987
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Lymphocyte Subsets
B-Lymphocytes
Obstructive Jaundice
gamma-Globulins
Ulcerative Colitis
Bilirubin
Liver Diseases
Fibrosis
Immunoglobulin G
T-Lymphocytes
Serum

Keywords

  • lymphocyte subset
  • primary sclerosing cholangitis
  • T-lymphocyte subsets

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lindor, K., Wiesner, R. H., Katzmann, J. A., Larusso, N. F., & Beaver, S. J. (1987). Lymphocyte subsets in primary sclerosing cholangitis. Digestive Diseases and Sciences, 32(7), 720-725. https://doi.org/10.1007/BF01296138

Lymphocyte subsets in primary sclerosing cholangitis. / Lindor, Keith; Wiesner, Russell H.; Katzmann, Jerry A.; Larusso, Nicholas F.; Beaver, Sandra J.

In: Digestive Diseases and Sciences, Vol. 32, No. 7, 07.1987, p. 720-725.

Research output: Contribution to journalArticle

Lindor, K, Wiesner, RH, Katzmann, JA, Larusso, NF & Beaver, SJ 1987, 'Lymphocyte subsets in primary sclerosing cholangitis', Digestive Diseases and Sciences, vol. 32, no. 7, pp. 720-725. https://doi.org/10.1007/BF01296138
Lindor, Keith ; Wiesner, Russell H. ; Katzmann, Jerry A. ; Larusso, Nicholas F. ; Beaver, Sandra J. / Lymphocyte subsets in primary sclerosing cholangitis. In: Digestive Diseases and Sciences. 1987 ; Vol. 32, No. 7. pp. 720-725.
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