Lunatic fringe null female mice are infertile due to defects in meiotic maturation

Katherine L. Hahn, Joshua Johnson, Brian J. Beres, Sheena Howard, Norma Wilson-Rawls

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

We have demonstrated that Notch genes are expressed in developing mammalian ovarian follicles. Lunatic fringe is an important regulator of Notch signaling. In this study, data are presented that demonstrate that radical fringe and lunatic fringe are expressed in the granulosa cells of developing follicles. Lunatic fringe null female mice were found to be infertile. Histological analysis of the lunatic fringe-deficient ovary demonstrated aberrant folliculogenesis. Furthermore, oocytes from these mutants did not complete meiotic maturation. This is a novel observation because this is the first report describing a meiotic defect that results from mutations in genes that are expressed in the somatic granulosa cells and not the oocytes. This represent's a new role for the Notch signaling pathway and lunatic fringe in mammalian folliculogenesis.

Original languageEnglish (US)
Pages (from-to)817-828
Number of pages12
JournalDevelopment
Volume132
Issue number4
DOIs
StatePublished - Feb 2005

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Granulosa Cells
Oocytes
defect
maturation
Ovarian Follicle
gene
Genes
Ovary
mutation
Observation
Mutation
mutant
analysis

Keywords

  • Fertility
  • Follicle
  • Lunatic fringe
  • Meiosis
  • Notch
  • Ovary

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Lunatic fringe null female mice are infertile due to defects in meiotic maturation. / Hahn, Katherine L.; Johnson, Joshua; Beres, Brian J.; Howard, Sheena; Wilson-Rawls, Norma.

In: Development, Vol. 132, No. 4, 02.2005, p. 817-828.

Research output: Contribution to journalArticle

Hahn, Katherine L. ; Johnson, Joshua ; Beres, Brian J. ; Howard, Sheena ; Wilson-Rawls, Norma. / Lunatic fringe null female mice are infertile due to defects in meiotic maturation. In: Development. 2005 ; Vol. 132, No. 4. pp. 817-828.
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