Low mineral density of a weight-bearing bone among adult women in a high fertility population

Jonathan Stieglitz, Bret A. Beheim, Benjamin Trumble, Felicia C. Madimenos, Hillard Kaplan, Michael Gurven

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Evolutionary theories of aging posit that greater reproductive effort causes somatic decline given a fundamental trade-off between investing energy in reproduction and repair. Few studies in high fertility human populations support this hypothesis, and problems of phenotypic correlation can obscure the expected trade-off between reproduction and somatic condition. This cross-sectional study investigates whether greater reproductive effort is associated with reduced calcaneal bone mineral density (BMD) among female Tsimane forager-farmers of lowland Bolivia. We also investigate whether female Tsimane BMD values are lower than sex- and age-matched US reference values, despite the fact that Tsimane engage in higher physical activity levels that can increase mechanical loading. To measure calcaneal BMD, quantitative ultrasonography was performed on 130 women (mean±SD age=36.6±15.7, range=15-75) that were recruited regardless of past or current reproductive status. Anthropometric and demographic data were collected during routine medical exams. As predicted, higher parity, short inter-birth interval, and earlier age at first birth are associated with reduced BMD among Tsimane women after adjusting for potential confounders. Population-level differences are apparent prior to the onset of reproduction, and age-related decline in BMD is greater among Tsimane compared with American women. Greater cumulative reproductive burden may lower calcaneal BMD individually and jointly with other lifestyle and heritable factors. Fitness impacts of kin transfers in adulthood may determine the value of investments in bone remodeling, and thus affect selection on age-profiles of bone mineral loss. Am J Phys Anthropol 156:637-648, 2015.

Original languageEnglish (US)
Pages (from-to)637-648
Number of pages12
JournalAmerican Journal of Physical Anthropology
Volume156
Issue number4
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

Fingerprint

Population Growth
Weight-Bearing
Bone Density
Minerals
fertility
Bone and Bones
Reproduction
evolutionary theory
demographic situation
Birth Intervals
Bolivia
Birth Order
fitness
cross-sectional study
Bone Remodeling
adulthood
Values
Parity
Age of Onset
farmer

Keywords

  • calcaneus
  • disposable soma
  • maternal depletion
  • quantitative ultrasonography
  • Tsimane

ASJC Scopus subject areas

  • Anatomy
  • Anthropology

Cite this

Low mineral density of a weight-bearing bone among adult women in a high fertility population. / Stieglitz, Jonathan; Beheim, Bret A.; Trumble, Benjamin; Madimenos, Felicia C.; Kaplan, Hillard; Gurven, Michael.

In: American Journal of Physical Anthropology, Vol. 156, No. 4, 01.04.2015, p. 637-648.

Research output: Contribution to journalArticle

Stieglitz, Jonathan ; Beheim, Bret A. ; Trumble, Benjamin ; Madimenos, Felicia C. ; Kaplan, Hillard ; Gurven, Michael. / Low mineral density of a weight-bearing bone among adult women in a high fertility population. In: American Journal of Physical Anthropology. 2015 ; Vol. 156, No. 4. pp. 637-648.
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