We have performed a Raman study of the low frequency modes in three oligo- and polynucleotides in Z-conformation, and we compare the spectra of these samples to those of two polynucleotides in B-conformation. In Z-DNA we find 5 intrahelical modes below 200 cm−1, in addition to the interhelical mode near 30 cm−1 which is only observed in crystalline samples. The most prominent intrahelical mode has a frequency of about 105 cm−1, close to the frequency of the strongest intrahelical mode in A-and B-DNA The sequence dependence of the frequency of this mode is considerably larger than for the same mode in B-DNA The other modes are less pronounced, and their frequency variations with base sequence are within the experimental accuracy.
|Original language||English (US)|
|Number of pages||10|
|Journal||Journal of Biomolecular Structure and Dynamics|
|State||Published - Feb 1990|
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology