Abstract
We have performed a Raman study of the low frequency modes in three oligo- and polynucleotides in Z-conformation, and we compare the spectra of these samples to those of two polynucleotides in B-conformation. In Z-DNA we find 5 intrahelical modes below 200 cm−1, in addition to the interhelical mode near 30 cm−1 which is only observed in crystalline samples. The most prominent intrahelical mode has a frequency of about 105 cm−1, close to the frequency of the strongest intrahelical mode in A-and B-DNA The sequence dependence of the frequency of this mode is considerably larger than for the same mode in B-DNA The other modes are less pronounced, and their frequency variations with base sequence are within the experimental accuracy.
Original language | English (US) |
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Pages (from-to) | 849-858 |
Number of pages | 10 |
Journal | Journal of Biomolecular Structure and Dynamics |
Volume | 7 |
Issue number | 4 |
DOIs | |
State | Published - Feb 1990 |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology