Low frequency raman spectra of Z-DNA

T. Weidlich, Stuart Lindsay, W. L. Peticolas, G. A. Thomas

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We have performed a Raman study of the low frequency modes in three oligo- and polynucleotides in Z-conformation, and we compare the spectra of these samples to those of two polynucleotides in B-conformation. In Z-DNA we find 5 intrahelical modes below 200 cm−1, in addition to the interhelical mode near 30 cm−1 which is only observed in crystalline samples. The most prominent intrahelical mode has a frequency of about 105 cm−1, close to the frequency of the strongest intrahelical mode in A-and B-DNA The sequence dependence of the frequency of this mode is considerably larger than for the same mode in B-DNA The other modes are less pronounced, and their frequency variations with base sequence are within the experimental accuracy.

Original languageEnglish (US)
Pages (from-to)849-858
Number of pages10
JournalJournal of Biomolecular Structure and Dynamics
Volume7
Issue number4
DOIs
StatePublished - Feb 1990

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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