Loss of cannabinoid receptor 1 accelerates intestinal tumor growth

Dingzhi Wang, Haibin Wang, Wei Ning, Michael G. Backlund, Sudhansu K. Dey, Raymond N. DuBois

Research output: Contribution to journalArticle

111 Scopus citations

Abstract

Although endocannabinoid signaling is important for certain aspects of gastrointestinal homeostasis, the role of the cannabinoid receptors (CB) in colorectal cancer has not been defined. Here we show that CB1 expression was silenced in human colorectal cancer due to methylation of the CB1 promoter. Our genetic and pharmacologic studies reveal that loss or inhibition of CB1 accelerated intestinal adenoma growth in ApcMin/+ mice whereas activation of CB1 attenuated intestinal tumor growth by inducing cell death via down-regulation of the antiapoptotic factor survivin. This down-regulation of survivin by CB1 is mediated by a cyclic AMP-dependent protein kinase A signaling pathway. These results indicate that the endogenous cannabinoid system may represent a potential therapeutic target for prevention or treatment of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)6468-6476
Number of pages9
JournalCancer Research
Volume68
Issue number15
DOIs
StatePublished - Aug 1 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Wang, D., Wang, H., Ning, W., Backlund, M. G., Dey, S. K., & DuBois, R. N. (2008). Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Research, 68(15), 6468-6476. https://doi.org/10.1158/0008-5472.CAN-08-0896