Longitudinal trajectories of hippocampal and prefrontal contributions to episodic retrieval: Effects of age and puberty

Diana Selmeczy, Yana Fandakova, Kevin Grimm, Silvia A. Bunge, Simona Ghetti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The current study investigated longitudinal change in hippocampal and prefrontal contribution to episodic retrieval. Functional neuroimaging data were collected during an item-context association memory task for children between the ages of 8 and 14 with individuals scanned 1–3 times over the course of 0.75–3.7 years (Timepoint 1 N = 90; Timepoint 2 N = 83, Timepoint 3 N = 75). We investigated developmental changes in functional activation associated with episodic retrieval (correct item-context > incorrect item-context contrast) and asked whether pubertal changes contributed to developmental changes in pattern of activation. Non-linear developmental trajectories were observed. In the hippocampus, activation decreased with age during childhood and then increased into early adolescence. In the dorsolateral prefrontal cortex, activation was largely absent initially, but quickly accelerated over time. Independent of age, changes in pubertal status additionally predicted increases in item-context activation in initially older children, and decreases in initially younger children across both regions and two indicators of puberty: the Pubertal Development Scale and salivary testosterone. These findings suggest that changes in both age and pubertal status uniquely contribute to memory-related activation, and the timing of pubertal onset may play an important role in the neural mechanisms supporting memory retrieval.

Original languageEnglish (US)
JournalDevelopmental Cognitive Neuroscience
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Puberty
Functional Neuroimaging
Prefrontal Cortex
Longitudinal Studies
Testosterone
Hippocampus

Keywords

  • DLPFC
  • Episodic memory
  • Hippocampus
  • Longitudinal
  • Puberty
  • Testosterone

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Longitudinal trajectories of hippocampal and prefrontal contributions to episodic retrieval : Effects of age and puberty. / Selmeczy, Diana; Fandakova, Yana; Grimm, Kevin; Bunge, Silvia A.; Ghetti, Simona.

In: Developmental Cognitive Neuroscience, 01.01.2018.

Research output: Contribution to journalArticle

@article{aa09f000294a4604b0f5fcac91222c66,
title = "Longitudinal trajectories of hippocampal and prefrontal contributions to episodic retrieval: Effects of age and puberty",
abstract = "The current study investigated longitudinal change in hippocampal and prefrontal contribution to episodic retrieval. Functional neuroimaging data were collected during an item-context association memory task for children between the ages of 8 and 14 with individuals scanned 1–3 times over the course of 0.75–3.7 years (Timepoint 1 N = 90; Timepoint 2 N = 83, Timepoint 3 N = 75). We investigated developmental changes in functional activation associated with episodic retrieval (correct item-context > incorrect item-context contrast) and asked whether pubertal changes contributed to developmental changes in pattern of activation. Non-linear developmental trajectories were observed. In the hippocampus, activation decreased with age during childhood and then increased into early adolescence. In the dorsolateral prefrontal cortex, activation was largely absent initially, but quickly accelerated over time. Independent of age, changes in pubertal status additionally predicted increases in item-context activation in initially older children, and decreases in initially younger children across both regions and two indicators of puberty: the Pubertal Development Scale and salivary testosterone. These findings suggest that changes in both age and pubertal status uniquely contribute to memory-related activation, and the timing of pubertal onset may play an important role in the neural mechanisms supporting memory retrieval.",
keywords = "DLPFC, Episodic memory, Hippocampus, Longitudinal, Puberty, Testosterone",
author = "Diana Selmeczy and Yana Fandakova and Kevin Grimm and Bunge, {Silvia A.} and Simona Ghetti",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.dcn.2018.10.003",
language = "English (US)",
journal = "Developmental Cognitive Neuroscience",
issn = "1878-9293",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Longitudinal trajectories of hippocampal and prefrontal contributions to episodic retrieval

T2 - Effects of age and puberty

AU - Selmeczy, Diana

AU - Fandakova, Yana

AU - Grimm, Kevin

AU - Bunge, Silvia A.

AU - Ghetti, Simona

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The current study investigated longitudinal change in hippocampal and prefrontal contribution to episodic retrieval. Functional neuroimaging data were collected during an item-context association memory task for children between the ages of 8 and 14 with individuals scanned 1–3 times over the course of 0.75–3.7 years (Timepoint 1 N = 90; Timepoint 2 N = 83, Timepoint 3 N = 75). We investigated developmental changes in functional activation associated with episodic retrieval (correct item-context > incorrect item-context contrast) and asked whether pubertal changes contributed to developmental changes in pattern of activation. Non-linear developmental trajectories were observed. In the hippocampus, activation decreased with age during childhood and then increased into early adolescence. In the dorsolateral prefrontal cortex, activation was largely absent initially, but quickly accelerated over time. Independent of age, changes in pubertal status additionally predicted increases in item-context activation in initially older children, and decreases in initially younger children across both regions and two indicators of puberty: the Pubertal Development Scale and salivary testosterone. These findings suggest that changes in both age and pubertal status uniquely contribute to memory-related activation, and the timing of pubertal onset may play an important role in the neural mechanisms supporting memory retrieval.

AB - The current study investigated longitudinal change in hippocampal and prefrontal contribution to episodic retrieval. Functional neuroimaging data were collected during an item-context association memory task for children between the ages of 8 and 14 with individuals scanned 1–3 times over the course of 0.75–3.7 years (Timepoint 1 N = 90; Timepoint 2 N = 83, Timepoint 3 N = 75). We investigated developmental changes in functional activation associated with episodic retrieval (correct item-context > incorrect item-context contrast) and asked whether pubertal changes contributed to developmental changes in pattern of activation. Non-linear developmental trajectories were observed. In the hippocampus, activation decreased with age during childhood and then increased into early adolescence. In the dorsolateral prefrontal cortex, activation was largely absent initially, but quickly accelerated over time. Independent of age, changes in pubertal status additionally predicted increases in item-context activation in initially older children, and decreases in initially younger children across both regions and two indicators of puberty: the Pubertal Development Scale and salivary testosterone. These findings suggest that changes in both age and pubertal status uniquely contribute to memory-related activation, and the timing of pubertal onset may play an important role in the neural mechanisms supporting memory retrieval.

KW - DLPFC

KW - Episodic memory

KW - Hippocampus

KW - Longitudinal

KW - Puberty

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=85058240363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058240363&partnerID=8YFLogxK

U2 - 10.1016/j.dcn.2018.10.003

DO - 10.1016/j.dcn.2018.10.003

M3 - Article

C2 - 30553718

AN - SCOPUS:85058240363

JO - Developmental Cognitive Neuroscience

JF - Developmental Cognitive Neuroscience

SN - 1878-9293

ER -