TY - JOUR
T1 - Longitudinal changes in insulin sensitivity, insulin secretion, and β-cell function during puberty
AU - Ball, Geoff D.C.
AU - Huang, Terry T.K.
AU - Gower, Barbara A.
AU - Cruz, Martha L.
AU - Shaibi, Gabriel Q.
AU - Weigensberg, Marc J.
AU - Goran, Michael I.
PY - 2006/1
Y1 - 2006/1
N2 - Objective: To determine longitudinal changes in insulin sensitivity (SI), insulin secretion, and β-cell function during puberty in white and black youth. Study design: The tolbutamide-modified frequently sampled intravenous glucose tolerance test and minimal modeling were used to measure SI, the acute insulin response to glucose (AIRg), and β-cell function (disposition index, DI) in white (n = 46) and black (n = 46) children (mean [±SD] age at baseline = 10.2 ± 1.7 years). Growth curve models (including 272 observations) with SI, AIRg, and DI regressed on Tanner stage were run after adjusting for covariates. Results: After adjusting for covariates, growth curve models revealed that SI decreased and subsequently recovered by the end of puberty in whites and blacks (both p < .05), AIRg decreased linearly across Tanner stages in both races (both p < .001), and DI decreased across puberty in blacks (p = .001) but not in whites (p = .2). Conclusions: White and black youth exhibited transient insulin resistance and diminished AIRg during puberty. The progressive decline in DI among blacks versus whites may reflect a unique effect of puberty on β-cell compensation in blacks. Future studies are needed to identify whether this difference contributes to the increased risk of type II diabetes in young blacks.
AB - Objective: To determine longitudinal changes in insulin sensitivity (SI), insulin secretion, and β-cell function during puberty in white and black youth. Study design: The tolbutamide-modified frequently sampled intravenous glucose tolerance test and minimal modeling were used to measure SI, the acute insulin response to glucose (AIRg), and β-cell function (disposition index, DI) in white (n = 46) and black (n = 46) children (mean [±SD] age at baseline = 10.2 ± 1.7 years). Growth curve models (including 272 observations) with SI, AIRg, and DI regressed on Tanner stage were run after adjusting for covariates. Results: After adjusting for covariates, growth curve models revealed that SI decreased and subsequently recovered by the end of puberty in whites and blacks (both p < .05), AIRg decreased linearly across Tanner stages in both races (both p < .001), and DI decreased across puberty in blacks (p = .001) but not in whites (p = .2). Conclusions: White and black youth exhibited transient insulin resistance and diminished AIRg during puberty. The progressive decline in DI among blacks versus whites may reflect a unique effect of puberty on β-cell compensation in blacks. Future studies are needed to identify whether this difference contributes to the increased risk of type II diabetes in young blacks.
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U2 - 10.1016/j.jpeds.2005.08.059
DO - 10.1016/j.jpeds.2005.08.059
M3 - Article
C2 - 16423592
AN - SCOPUS:30744448677
SN - 0022-3476
VL - 148
SP - 16
EP - 22
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 1
ER -