Recent interest in high redshift cosmology observations with the redshifted 21cm line has rekindled exploration of the VHF radio band (50-200MHz) for radio astronomy. Single antenna instruments like the ground-based EDGES and the proposed lunar orbiting DARE have the goal of characterizing the global HI signal and extracting astrophysical and cosmological information. One limitation over much of the band is strong man-made and naturally occurring interference, which DARE avoids by observing as it orbits the far side of the moon. Another advantage of space-based observing is avoidance of the ionosphere which becomes increasingly reflective at the lower end of the VHF band. Technical challenges to this type of mission include development of lower power wide-band spectrometers, better mapping of Earth originating interference, and incorporation of lessons learned from ongoing ground-based experiments. One of the main challenges faced by EDGES, observing the narrower but clean stretch of bandwidth found in Western Australia, is calibrating the spectral response of the antenna at the required 0.01dB level.