Localization of hematoporphyrin. Derivative to human colorectal cancer

Robert S. Wooten; David A. Ahlquist; Robert E. Anderson; Herschel A. Carpenter; John H. Pemberton; Denis A. Cortese; Duane M. Ilstrup

doi:10.1002/1097-0142(19891015)64:8<1569::AID-CNCR2820640802>3.0.CO;2-G

Localization of hematoporphyrin. Derivative to human colorectal cancer

Robert S. Wooten, David A. Ahlquist, Robert E. Anderson, Herschel A. Carpenter, John H. Pemberton, Denis A. Cortese, Duane M. Ilstrup

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

This study documents the affinity of hematoporphyrin derivative (HpD) for human colorectal cancer by analysis of surface fluorescence. Ten patients undergoing elective surgery for primary colorectal cancer received intravenous HpD (2–5 mg/kg) either 3 or 72 hours preoperatively. Fluorescent photographs were taken of freshly resected specimens and analyzed using a computerized videodensitometric technique. This technique subtracted contaminating non‐HpD fluorescence and facilitated estimation of HpD tissue levels. The HpD‐specific fluorescence localized to tumors in all cases, and the mean HpD concentration was six‐fold greater in malignant tissue than in surrounding normal mucosa (0.6 μg/g versus 0.1 μg/g, P < 0.001). The authors conclude that HpD preferentially localizes to human colorectal cancer and this is relevant to the photodetection and phototherapy of colorectal neoplasia.

Original language	English (US)
Pages (from-to)	1569-1576
Number of pages	8
Journal	Cancer
Volume	64
Issue number	8
DOIs	https://doi.org/10.1002/1097-0142(19891015)64:8<1569::AID-CNCR2820640802>3.0.CO;2-G
State	Published - Oct 15 1989
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19891015)64:8<1569::AID-CNCR2820640802>3.0.CO;2-G

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title = "Localization of hematoporphyrin. Derivative to human colorectal cancer",

abstract = "This study documents the affinity of hematoporphyrin derivative (HpD) for human colorectal cancer by analysis of surface fluorescence. Ten patients undergoing elective surgery for primary colorectal cancer received intravenous HpD (2–5 mg/kg) either 3 or 72 hours preoperatively. Fluorescent photographs were taken of freshly resected specimens and analyzed using a computerized videodensitometric technique. This technique subtracted contaminating non‐HpD fluorescence and facilitated estimation of HpD tissue levels. The HpD‐specific fluorescence localized to tumors in all cases, and the mean HpD concentration was six‐fold greater in malignant tissue than in surrounding normal mucosa (0.6 μg/g versus 0.1 μg/g, P < 0.001). The authors conclude that HpD preferentially localizes to human colorectal cancer and this is relevant to the photodetection and phototherapy of colorectal neoplasia.",

author = "Wooten, {Robert S.} and Ahlquist, {David A.} and Anderson, {Robert E.} and Carpenter, {Herschel A.} and Pemberton, {John H.} and Cortese, {Denis A.} and Ilstrup, {Duane M.}",

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AU - Wooten, Robert S.

AU - Ahlquist, David A.

AU - Anderson, Robert E.

AU - Carpenter, Herschel A.

AU - Pemberton, John H.

AU - Cortese, Denis A.

AU - Ilstrup, Duane M.

PY - 1989/10/15

Y1 - 1989/10/15

N2 - This study documents the affinity of hematoporphyrin derivative (HpD) for human colorectal cancer by analysis of surface fluorescence. Ten patients undergoing elective surgery for primary colorectal cancer received intravenous HpD (2–5 mg/kg) either 3 or 72 hours preoperatively. Fluorescent photographs were taken of freshly resected specimens and analyzed using a computerized videodensitometric technique. This technique subtracted contaminating non‐HpD fluorescence and facilitated estimation of HpD tissue levels. The HpD‐specific fluorescence localized to tumors in all cases, and the mean HpD concentration was six‐fold greater in malignant tissue than in surrounding normal mucosa (0.6 μg/g versus 0.1 μg/g, P < 0.001). The authors conclude that HpD preferentially localizes to human colorectal cancer and this is relevant to the photodetection and phototherapy of colorectal neoplasia.

AB - This study documents the affinity of hematoporphyrin derivative (HpD) for human colorectal cancer by analysis of surface fluorescence. Ten patients undergoing elective surgery for primary colorectal cancer received intravenous HpD (2–5 mg/kg) either 3 or 72 hours preoperatively. Fluorescent photographs were taken of freshly resected specimens and analyzed using a computerized videodensitometric technique. This technique subtracted contaminating non‐HpD fluorescence and facilitated estimation of HpD tissue levels. The HpD‐specific fluorescence localized to tumors in all cases, and the mean HpD concentration was six‐fold greater in malignant tissue than in surrounding normal mucosa (0.6 μg/g versus 0.1 μg/g, P < 0.001). The authors conclude that HpD preferentially localizes to human colorectal cancer and this is relevant to the photodetection and phototherapy of colorectal neoplasia.

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Localization of hematoporphyrin. Derivative to human colorectal cancer

Abstract

ASJC Scopus subject areas

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