Localization of hematoporphyrin. Derivative to human colorectal cancer

Robert S. Wooten, David A. Ahlquist, Robert E. Anderson, Herschel A. Carpenter, John H. Pemberton, Denis A. Cortese, Duane M. Ilstrup

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Abstract

This study documents the affinity of hematoporphyrin derivative (HpD) for human colorectal cancer by analysis of surface fluorescence. Ten patients undergoing elective surgery for primary colorectal cancer received intravenous HpD (2–5 mg/kg) either 3 or 72 hours preoperatively. Fluorescent photographs were taken of freshly resected specimens and analyzed using a computerized videodensitometric technique. This technique subtracted contaminating non‐HpD fluorescence and facilitated estimation of HpD tissue levels. The HpD‐specific fluorescence localized to tumors in all cases, and the mean HpD concentration was six‐fold greater in malignant tissue than in surrounding normal mucosa (0.6 μg/g versus 0.1 μg/g, P < 0.001). The authors conclude that HpD preferentially localizes to human colorectal cancer and this is relevant to the photodetection and phototherapy of colorectal neoplasia.

Original languageEnglish (US)
Pages (from-to)1569-1576
Number of pages8
JournalCancer
Volume64
Issue number8
DOIs
StatePublished - Oct 15 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Wooten, R. S., Ahlquist, D. A., Anderson, R. E., Carpenter, H. A., Pemberton, J. H., Cortese, D. A., & Ilstrup, D. M. (1989). Localization of hematoporphyrin. Derivative to human colorectal cancer. Cancer, 64(8), 1569-1576. https://doi.org/10.1002/1097-0142(19891015)64:8<1569::AID-CNCR2820640802>3.0.CO;2-G