Abstract
Lithium has been reported to inhibit opioid-induced properties. The present study examined the effect of acute and chronic administration of lithium chloride (LiCl) on morphine's biphasic modulation of susceptibility to pentylenetetrazole (PTZ)-induced clonic seizure in mice. We also examined the possible involvement of nitric oxide (NO) pathway in lithium effect. Both acute (0.1 and 1 mg/kg) and chronic (same doses, 21 consecutive days) administration of LiCl completely inhibited the anticonvulsant and proconvulsant effects of morphine (at doses 1 and 30 mg/kg, respectively). A very low and per se noneffective dose of LiCl (0.05 mg/kg) significantly inhibited both phases of morphine effect when administered concomitant with a noneffective low dose of naloxone (0.1 mg/kg). The NO synthase inhibitor N G-nitro-l-arginine methyl ester (L-NAME) at a per se noneffective dose of 0.3 mg/kg potentiated the inhibitory effects of low doses of LiCl (0.01 and 0.05 mg/kg) on both phases of morphine effect. l-arginine, a NO synthase substrate, at a per se noneffective dose of 30 mg/kg reversed the inhibitory effects of lithium (1 mg/kg). Lithium is capable of antagonizing both modulatory effects of morphine on seizure susceptibility even at relatively low doses. These inhibitory effects of lithium may also involve NO synthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 48-55 |
| Number of pages | 8 |
| Journal | Brain Research |
| Volume | 1029 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 10 2004 |
| Externally published | Yes |
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Keywords
- Clonic seizure threshold
- Lithium
- Morphine
- Mouse
- Nitric oxide
- Pentylenetetrazole
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Lithium inhibits the modulatory effects of morphine on susceptibility to pentylenetetrazole-induced clonic seizure in mice : Involvement of a nitric oxide pathway. / Honar, Hooman; Riazi, Kiarash; Homayoun, Houman; Demehri, Shadpour; Dehghani, Mehdi; Vafaie, Kourosh; Ebrahimkhani, Mohammad; Rashidi, Narges; Gaskari, Seyed Ali; Dehpour, Ahmad Reza.
In: Brain Research, Vol. 1029, No. 1, 10.12.2004, p. 48-55.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lithium inhibits the modulatory effects of morphine on susceptibility to pentylenetetrazole-induced clonic seizure in mice
T2 - Involvement of a nitric oxide pathway
AU - Honar, Hooman
AU - Riazi, Kiarash
AU - Homayoun, Houman
AU - Demehri, Shadpour
AU - Dehghani, Mehdi
AU - Vafaie, Kourosh
AU - Ebrahimkhani, Mohammad
AU - Rashidi, Narges
AU - Gaskari, Seyed Ali
AU - Dehpour, Ahmad Reza
PY - 2004/12/10
Y1 - 2004/12/10
N2 - Lithium has been reported to inhibit opioid-induced properties. The present study examined the effect of acute and chronic administration of lithium chloride (LiCl) on morphine's biphasic modulation of susceptibility to pentylenetetrazole (PTZ)-induced clonic seizure in mice. We also examined the possible involvement of nitric oxide (NO) pathway in lithium effect. Both acute (0.1 and 1 mg/kg) and chronic (same doses, 21 consecutive days) administration of LiCl completely inhibited the anticonvulsant and proconvulsant effects of morphine (at doses 1 and 30 mg/kg, respectively). A very low and per se noneffective dose of LiCl (0.05 mg/kg) significantly inhibited both phases of morphine effect when administered concomitant with a noneffective low dose of naloxone (0.1 mg/kg). The NO synthase inhibitor N G-nitro-l-arginine methyl ester (L-NAME) at a per se noneffective dose of 0.3 mg/kg potentiated the inhibitory effects of low doses of LiCl (0.01 and 0.05 mg/kg) on both phases of morphine effect. l-arginine, a NO synthase substrate, at a per se noneffective dose of 30 mg/kg reversed the inhibitory effects of lithium (1 mg/kg). Lithium is capable of antagonizing both modulatory effects of morphine on seizure susceptibility even at relatively low doses. These inhibitory effects of lithium may also involve NO synthesis.
AB - Lithium has been reported to inhibit opioid-induced properties. The present study examined the effect of acute and chronic administration of lithium chloride (LiCl) on morphine's biphasic modulation of susceptibility to pentylenetetrazole (PTZ)-induced clonic seizure in mice. We also examined the possible involvement of nitric oxide (NO) pathway in lithium effect. Both acute (0.1 and 1 mg/kg) and chronic (same doses, 21 consecutive days) administration of LiCl completely inhibited the anticonvulsant and proconvulsant effects of morphine (at doses 1 and 30 mg/kg, respectively). A very low and per se noneffective dose of LiCl (0.05 mg/kg) significantly inhibited both phases of morphine effect when administered concomitant with a noneffective low dose of naloxone (0.1 mg/kg). The NO synthase inhibitor N G-nitro-l-arginine methyl ester (L-NAME) at a per se noneffective dose of 0.3 mg/kg potentiated the inhibitory effects of low doses of LiCl (0.01 and 0.05 mg/kg) on both phases of morphine effect. l-arginine, a NO synthase substrate, at a per se noneffective dose of 30 mg/kg reversed the inhibitory effects of lithium (1 mg/kg). Lithium is capable of antagonizing both modulatory effects of morphine on seizure susceptibility even at relatively low doses. These inhibitory effects of lithium may also involve NO synthesis.
KW - Clonic seizure threshold
KW - Lithium
KW - Morphine
KW - Mouse
KW - Nitric oxide
KW - Pentylenetetrazole
UR - http://www.scopus.com/inward/record.url?scp=7744224923&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7744224923&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2004.09.018
DO - 10.1016/j.brainres.2004.09.018
M3 - Article
VL - 1029
SP - 48
EP - 55
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -