Linking temperamental fearfulness and anxiety symptoms: A behavior-genetic perspective

H. H. Goldsmith, Kathryn Lemery

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Research on mood and anxiety disorders has historically proceeded without sufficient reference to the growing body of work on the nature of typical emotional development and temperament. Reviewing data from several studies, we consider experiential, biological, and genetic factors as providing causal input to typical developmental variation in fearfulness and anxiety during infancy and early childhood. Longitudinal behavioral methods, psychophysiologic measures, and a behavior-genetic framework are used to approach these issues. Results from twin studies implicate moderately strong genetic influences on different facets of temperamental fearfulness, as well as childhood anxiety symptoms. Then, we consider the distinction between normal range temperament and overt anxiety symptoms from a quantitative genetic perspective. Biological correlates (cortisol, asymmetric frontal EEG activation, cardiac reactivity) of inhibited behavior are considered as related endophenotypes for anxiety. In a nongenetic analysis, we report the prediction of internalizing problems during kindergarten from earlier temperament and earlier basal cortisol measures. Our review highlights connections between behavioral indicators and various putative endophenotypes and the fuzzy boundary between normal-range temperament and anxiety disorders.

Original languageEnglish (US)
Pages (from-to)1199-1209
Number of pages11
JournalBiological Psychiatry
Volume48
Issue number12
DOIs
StatePublished - Dec 15 2000
Externally publishedYes

Fingerprint

Temperament
Anxiety
Endophenotypes
Anxiety Disorders
Hydrocortisone
Reference Values
Twin Studies
Biological Factors
Mood Disorders
Electroencephalography
Research

Keywords

  • Anxiety
  • Childhood
  • Fear
  • Genetics
  • Temperament
  • Twins

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Linking temperamental fearfulness and anxiety symptoms : A behavior-genetic perspective. / Goldsmith, H. H.; Lemery, Kathryn.

In: Biological Psychiatry, Vol. 48, No. 12, 15.12.2000, p. 1199-1209.

Research output: Contribution to journalArticle

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