Linking a mutation to survival in wild mice

Rowan D.H. Barrett, Stefan Laurent, Ricardo Mallarino, Susanne Pfeifer, Charles C.Y. Xu, Matthieu Foll, Kazumasa Wakamatsu, Jonathan S. Duke-Cohan, Jeffrey Jensen, Hopi E. Hoekstra

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Adaptive evolution in new or changing environments can be difficult to predict because the functional connections between genotype, phenotype, and fitness are complex. Here, we make these explicit connections by combining field and laboratory experiments in wild mice. We first directly estimate natural selection on pigmentation traits and an underlying pigment locus, Agouti, by using experimental enclosures of mice on different soil colors. Next, we show how a mutation in Agouti associated with survival causes lighter coat color through changes in its protein binding properties. Together, our findings demonstrate how a sequence variant alters phenotype and then reveal the ensuing ecological consequences that drive changes in population allele frequency, thereby illuminating the process of evolution by natural selection.

Original languageEnglish (US)
Pages (from-to)499-504
Number of pages6
JournalScience
Volume363
Issue number6426
DOIs
StatePublished - Feb 1 2019

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Genetic Selection
Color
Phenotype
Mutation
Pigmentation
Protein Binding
Gene Frequency
Soil
Genotype
Population
Dasyproctidae

ASJC Scopus subject areas

  • General

Cite this

Barrett, R. D. H., Laurent, S., Mallarino, R., Pfeifer, S., Xu, C. C. Y., Foll, M., ... Hoekstra, H. E. (2019). Linking a mutation to survival in wild mice. Science, 363(6426), 499-504. https://doi.org/10.1126/science.aav3824

Linking a mutation to survival in wild mice. / Barrett, Rowan D.H.; Laurent, Stefan; Mallarino, Ricardo; Pfeifer, Susanne; Xu, Charles C.Y.; Foll, Matthieu; Wakamatsu, Kazumasa; Duke-Cohan, Jonathan S.; Jensen, Jeffrey; Hoekstra, Hopi E.

In: Science, Vol. 363, No. 6426, 01.02.2019, p. 499-504.

Research output: Contribution to journalArticle

Barrett, RDH, Laurent, S, Mallarino, R, Pfeifer, S, Xu, CCY, Foll, M, Wakamatsu, K, Duke-Cohan, JS, Jensen, J & Hoekstra, HE 2019, 'Linking a mutation to survival in wild mice', Science, vol. 363, no. 6426, pp. 499-504. https://doi.org/10.1126/science.aav3824
Barrett RDH, Laurent S, Mallarino R, Pfeifer S, Xu CCY, Foll M et al. Linking a mutation to survival in wild mice. Science. 2019 Feb 1;363(6426):499-504. https://doi.org/10.1126/science.aav3824
Barrett, Rowan D.H. ; Laurent, Stefan ; Mallarino, Ricardo ; Pfeifer, Susanne ; Xu, Charles C.Y. ; Foll, Matthieu ; Wakamatsu, Kazumasa ; Duke-Cohan, Jonathan S. ; Jensen, Jeffrey ; Hoekstra, Hopi E. / Linking a mutation to survival in wild mice. In: Science. 2019 ; Vol. 363, No. 6426. pp. 499-504.
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