Linkage analysis between Huntington Disease the the G8 marker locus

J. A. Badner, A. Chakravarti, Kenneth Buetow

Research output: Contribution to journalArticle

Abstract

Our analysis of four large HD families shows strong evidence for linkage to G8 (Z=22.32) with recombination values .057 for males and .070 for females. In spite of ethnic differences and clinical variation of HD in these families the evidence suggests a single locus for this disease. Fortunately, lod scores are relatively insensitive to variation in genetic parameters such as gene frequency, age at onset and inbreeding, so that accurate estimates of the recombination value may be obtained and used for clinical purposes.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalGenetic Epidemiology
Volume3
Issue numberSUPPL. 1
StatePublished - 1986
Externally publishedYes

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Huntington Disease
Genetic Recombination
Lod Score
Inbreeding
Age of Onset
Gene Frequency

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)
  • Medicine(all)

Cite this

Linkage analysis between Huntington Disease the the G8 marker locus. / Badner, J. A.; Chakravarti, A.; Buetow, Kenneth.

In: Genetic Epidemiology, Vol. 3, No. SUPPL. 1, 1986, p. 211-216.

Research output: Contribution to journalArticle

Badner, JA, Chakravarti, A & Buetow, K 1986, 'Linkage analysis between Huntington Disease the the G8 marker locus', Genetic Epidemiology, vol. 3, no. SUPPL. 1, pp. 211-216.
Badner, J. A. ; Chakravarti, A. ; Buetow, Kenneth. / Linkage analysis between Huntington Disease the the G8 marker locus. In: Genetic Epidemiology. 1986 ; Vol. 3, No. SUPPL. 1. pp. 211-216.
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