Limited physical contact through a mesh barrier is sufficient for social reward-conditioned place preference in adolescent male rats

Natalie A. Peartree, Lauren E. Hood, Kenneth J. Thiel, Federico Sanabria, Nathan S. Pentkowski, Kayla N. Chandler, Janet Neisewander

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Adolescence is a period of enhanced sensitivity to social influences and vulnerability to drug abuse. Social reward in adolescent rats has been demonstrated with the conditioned place preference (CPP) model, but it is not clear whether limited contact with another rat without play is sufficient to produce reward. We investigated this issue using an apparatus containing two main compartment, each with a wire mesh barrier that allowed rats placed on either side of the barrier to have limited physical contact. Adolescent male rats were given two conditioning sessions/day for 2 or 8. days following baseline preference tests. Rats were placed into their preferred side alone for one daily 10-min session and into their initially non-preferred side (i.e., CS) for the other session during which they either had restricted or unrestricted physical access to another rat (Rat/Mesh or Rat/Phys, respectively) or to a tennis ball (Ball/Mesh or Ball/Phys, respectively) unconditioned stimulus (US). Only the Rat/Phys group exhibited CPP after 2 CS-US pairings; however, after 8 CS-US pairings, the Rat/Mesh and Ball/Phys groups also exhibited CPP. During conditioning, the rat US elicited more robust approach and contact behavior compared to the ball, regardless of physical or restricted access. The incidence of contact and/or approach increased as the number of exposures increased. The results suggest that the rank order of US reward efficacy was physical contact with a rat > limited contact with a rat > physical contact with a ball, and that rough-and-tumble play is not necessary to establish social reward-CPP. The findings have important implications for emerging drug self-administration models in which two rats self-administering drug intravenously have limited physical contact via a mesh barrier shared between their respective operant conditioning chambers.

Original languageEnglish (US)
Pages (from-to)749-756
Number of pages8
JournalPhysiology and Behavior
Volume105
Issue number3
DOIs
StatePublished - Feb 1 2012

Fingerprint

Reward
Physical
Rat
Operant Conditioning
Tennis
Self Administration
Pharmaceutical Preparations
Substance-Related Disorders
Stimulus

Keywords

  • Adolescence
  • Drug self-administration
  • Place conditioning
  • Rough-and-tumble play behavior

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Philosophy

Cite this

Limited physical contact through a mesh barrier is sufficient for social reward-conditioned place preference in adolescent male rats. / Peartree, Natalie A.; Hood, Lauren E.; Thiel, Kenneth J.; Sanabria, Federico; Pentkowski, Nathan S.; Chandler, Kayla N.; Neisewander, Janet.

In: Physiology and Behavior, Vol. 105, No. 3, 01.02.2012, p. 749-756.

Research output: Contribution to journalArticle

Peartree, Natalie A. ; Hood, Lauren E. ; Thiel, Kenneth J. ; Sanabria, Federico ; Pentkowski, Nathan S. ; Chandler, Kayla N. ; Neisewander, Janet. / Limited physical contact through a mesh barrier is sufficient for social reward-conditioned place preference in adolescent male rats. In: Physiology and Behavior. 2012 ; Vol. 105, No. 3. pp. 749-756.
@article{243b1ec4b9ff43a3bf176c9043b36bc0,
title = "Limited physical contact through a mesh barrier is sufficient for social reward-conditioned place preference in adolescent male rats",
abstract = "Adolescence is a period of enhanced sensitivity to social influences and vulnerability to drug abuse. Social reward in adolescent rats has been demonstrated with the conditioned place preference (CPP) model, but it is not clear whether limited contact with another rat without play is sufficient to produce reward. We investigated this issue using an apparatus containing two main compartment, each with a wire mesh barrier that allowed rats placed on either side of the barrier to have limited physical contact. Adolescent male rats were given two conditioning sessions/day for 2 or 8. days following baseline preference tests. Rats were placed into their preferred side alone for one daily 10-min session and into their initially non-preferred side (i.e., CS) for the other session during which they either had restricted or unrestricted physical access to another rat (Rat/Mesh or Rat/Phys, respectively) or to a tennis ball (Ball/Mesh or Ball/Phys, respectively) unconditioned stimulus (US). Only the Rat/Phys group exhibited CPP after 2 CS-US pairings; however, after 8 CS-US pairings, the Rat/Mesh and Ball/Phys groups also exhibited CPP. During conditioning, the rat US elicited more robust approach and contact behavior compared to the ball, regardless of physical or restricted access. The incidence of contact and/or approach increased as the number of exposures increased. The results suggest that the rank order of US reward efficacy was physical contact with a rat > limited contact with a rat > physical contact with a ball, and that rough-and-tumble play is not necessary to establish social reward-CPP. The findings have important implications for emerging drug self-administration models in which two rats self-administering drug intravenously have limited physical contact via a mesh barrier shared between their respective operant conditioning chambers.",
keywords = "Adolescence, Drug self-administration, Place conditioning, Rough-and-tumble play behavior",
author = "Peartree, {Natalie A.} and Hood, {Lauren E.} and Thiel, {Kenneth J.} and Federico Sanabria and Pentkowski, {Nathan S.} and Chandler, {Kayla N.} and Janet Neisewander",
year = "2012",
month = "2",
day = "1",
doi = "10.1016/j.physbeh.2011.10.001",
language = "English (US)",
volume = "105",
pages = "749--756",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Limited physical contact through a mesh barrier is sufficient for social reward-conditioned place preference in adolescent male rats

AU - Peartree, Natalie A.

AU - Hood, Lauren E.

AU - Thiel, Kenneth J.

AU - Sanabria, Federico

AU - Pentkowski, Nathan S.

AU - Chandler, Kayla N.

AU - Neisewander, Janet

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Adolescence is a period of enhanced sensitivity to social influences and vulnerability to drug abuse. Social reward in adolescent rats has been demonstrated with the conditioned place preference (CPP) model, but it is not clear whether limited contact with another rat without play is sufficient to produce reward. We investigated this issue using an apparatus containing two main compartment, each with a wire mesh barrier that allowed rats placed on either side of the barrier to have limited physical contact. Adolescent male rats were given two conditioning sessions/day for 2 or 8. days following baseline preference tests. Rats were placed into their preferred side alone for one daily 10-min session and into their initially non-preferred side (i.e., CS) for the other session during which they either had restricted or unrestricted physical access to another rat (Rat/Mesh or Rat/Phys, respectively) or to a tennis ball (Ball/Mesh or Ball/Phys, respectively) unconditioned stimulus (US). Only the Rat/Phys group exhibited CPP after 2 CS-US pairings; however, after 8 CS-US pairings, the Rat/Mesh and Ball/Phys groups also exhibited CPP. During conditioning, the rat US elicited more robust approach and contact behavior compared to the ball, regardless of physical or restricted access. The incidence of contact and/or approach increased as the number of exposures increased. The results suggest that the rank order of US reward efficacy was physical contact with a rat > limited contact with a rat > physical contact with a ball, and that rough-and-tumble play is not necessary to establish social reward-CPP. The findings have important implications for emerging drug self-administration models in which two rats self-administering drug intravenously have limited physical contact via a mesh barrier shared between their respective operant conditioning chambers.

AB - Adolescence is a period of enhanced sensitivity to social influences and vulnerability to drug abuse. Social reward in adolescent rats has been demonstrated with the conditioned place preference (CPP) model, but it is not clear whether limited contact with another rat without play is sufficient to produce reward. We investigated this issue using an apparatus containing two main compartment, each with a wire mesh barrier that allowed rats placed on either side of the barrier to have limited physical contact. Adolescent male rats were given two conditioning sessions/day for 2 or 8. days following baseline preference tests. Rats were placed into their preferred side alone for one daily 10-min session and into their initially non-preferred side (i.e., CS) for the other session during which they either had restricted or unrestricted physical access to another rat (Rat/Mesh or Rat/Phys, respectively) or to a tennis ball (Ball/Mesh or Ball/Phys, respectively) unconditioned stimulus (US). Only the Rat/Phys group exhibited CPP after 2 CS-US pairings; however, after 8 CS-US pairings, the Rat/Mesh and Ball/Phys groups also exhibited CPP. During conditioning, the rat US elicited more robust approach and contact behavior compared to the ball, regardless of physical or restricted access. The incidence of contact and/or approach increased as the number of exposures increased. The results suggest that the rank order of US reward efficacy was physical contact with a rat > limited contact with a rat > physical contact with a ball, and that rough-and-tumble play is not necessary to establish social reward-CPP. The findings have important implications for emerging drug self-administration models in which two rats self-administering drug intravenously have limited physical contact via a mesh barrier shared between their respective operant conditioning chambers.

KW - Adolescence

KW - Drug self-administration

KW - Place conditioning

KW - Rough-and-tumble play behavior

UR - http://www.scopus.com/inward/record.url?scp=80155161359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80155161359&partnerID=8YFLogxK

U2 - 10.1016/j.physbeh.2011.10.001

DO - 10.1016/j.physbeh.2011.10.001

M3 - Article

VL - 105

SP - 749

EP - 756

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 3

ER -