Light Directed Solid Phase Synthesis on Patterned Polymers

Neal Woodbury (Inventor)

Research output: Patent

Abstract

Microarrays are commonly used in the analysis, identification, and quantification of the composition and properties of analytes. The typical density of microarray reactive sites is relatively low. This low density results in only weak fluorescent signals being generated from such microarrays during optical probing. Weak fluorescence signals necessitate the use of sensitive and expensive detection equipment for the analytical method. The present technology describes an array of chemically reactive sites comprising a plurality of substrates and a plurality of three-dimensional microstructures. The plurality of three-dimensional microstructures and substrates enables selective tailoring of reactivities. The higher concentration of reactive molecules enables the use of many less-sensitive analytical methods to probe the microarray. In the case of optical approaches, the sites will generally emit a higher intensity of light in a fluorescent array and provide greater contrast between reaction sites. Potential Applications This invention may be used in any microarray setting that requires analysis and processing of analytes. Benefits and Advantages Greater diagnostic sensitivity Enhanced reactive surface area with greater strength of functional properties Enhanced range of chemical reactivitiesDownload original PDFFor more information about the inventor(s) and their research, please see Dr. Woodbury's departmental webpageDr. Woodbury's directory webpage
Original languageEnglish (US)
StatePublished - Apr 21 2004

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Microarrays
Polymers
Microstructure
Patents and inventions
Substrates
Fluorescence
Molecules
Processing
Chemical analysis

Cite this

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title = "Light Directed Solid Phase Synthesis on Patterned Polymers",
abstract = "Microarrays are commonly used in the analysis, identification, and quantification of the composition and properties of analytes. The typical density of microarray reactive sites is relatively low. This low density results in only weak fluorescent signals being generated from such microarrays during optical probing. Weak fluorescence signals necessitate the use of sensitive and expensive detection equipment for the analytical method. The present technology describes an array of chemically reactive sites comprising a plurality of substrates and a plurality of three-dimensional microstructures. The plurality of three-dimensional microstructures and substrates enables selective tailoring of reactivities. The higher concentration of reactive molecules enables the use of many less-sensitive analytical methods to probe the microarray. In the case of optical approaches, the sites will generally emit a higher intensity of light in a fluorescent array and provide greater contrast between reaction sites. Potential Applications This invention may be used in any microarray setting that requires analysis and processing of analytes. Benefits and Advantages Greater diagnostic sensitivity Enhanced reactive surface area with greater strength of functional properties Enhanced range of chemical reactivitiesDownload original PDFFor more information about the inventor(s) and their research, please see Dr. Woodbury's departmental webpageDr. Woodbury's directory webpage",
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T1 - Light Directed Solid Phase Synthesis on Patterned Polymers

AU - Woodbury, Neal

PY - 2004/4/21

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N2 - Microarrays are commonly used in the analysis, identification, and quantification of the composition and properties of analytes. The typical density of microarray reactive sites is relatively low. This low density results in only weak fluorescent signals being generated from such microarrays during optical probing. Weak fluorescence signals necessitate the use of sensitive and expensive detection equipment for the analytical method. The present technology describes an array of chemically reactive sites comprising a plurality of substrates and a plurality of three-dimensional microstructures. The plurality of three-dimensional microstructures and substrates enables selective tailoring of reactivities. The higher concentration of reactive molecules enables the use of many less-sensitive analytical methods to probe the microarray. In the case of optical approaches, the sites will generally emit a higher intensity of light in a fluorescent array and provide greater contrast between reaction sites. Potential Applications This invention may be used in any microarray setting that requires analysis and processing of analytes. Benefits and Advantages Greater diagnostic sensitivity Enhanced reactive surface area with greater strength of functional properties Enhanced range of chemical reactivitiesDownload original PDFFor more information about the inventor(s) and their research, please see Dr. Woodbury's departmental webpageDr. Woodbury's directory webpage

AB - Microarrays are commonly used in the analysis, identification, and quantification of the composition and properties of analytes. The typical density of microarray reactive sites is relatively low. This low density results in only weak fluorescent signals being generated from such microarrays during optical probing. Weak fluorescence signals necessitate the use of sensitive and expensive detection equipment for the analytical method. The present technology describes an array of chemically reactive sites comprising a plurality of substrates and a plurality of three-dimensional microstructures. The plurality of three-dimensional microstructures and substrates enables selective tailoring of reactivities. The higher concentration of reactive molecules enables the use of many less-sensitive analytical methods to probe the microarray. In the case of optical approaches, the sites will generally emit a higher intensity of light in a fluorescent array and provide greater contrast between reaction sites. Potential Applications This invention may be used in any microarray setting that requires analysis and processing of analytes. Benefits and Advantages Greater diagnostic sensitivity Enhanced reactive surface area with greater strength of functional properties Enhanced range of chemical reactivitiesDownload original PDFFor more information about the inventor(s) and their research, please see Dr. Woodbury's departmental webpageDr. Woodbury's directory webpage

M3 - Patent

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